Evidence map›Paper›PMID 22361291›Full record

ArticleRNA (New York, N.Y.)2012

RNA-Puzzles: a CASP-like evaluation of RNA three-dimensional structure prediction.

José Almeida Cruz, Marc-Frédérick Blanchet, Michal Boniecki, Janusz M Bujnicki, Shi-Jie Chen, Song Cao, Rhiju Das, Feng Ding, Nikolay V Dokholyan, Samuel Coulbourn Flores and 23 more

Abstract read
In one paragraph

Article in RNA (New York, N.Y.), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 166 papers.

0numbers the graph read from it
0cells of the map it votes in
166citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

166 citing papers in PubMed.

  1. Article
  2. Perspective - RNA Dynamics Today and Tomorrow.Journal of molecular biology · 2026
    Review
  3. Review
  4. Article
  5. FRET-guided selection of RNA 3D structures.Nucleic acids research · 2026
    Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. De novo design of RNA and nucleoprotein complexes.bioRxiv : the preprint server for biology · 2025
    Article
  15. Article
  16. Article
  17. Predicting RNA Structure Utilizing Attention from Pretrained Language Models.Journal of chemical information and modeling · 2025
    Article
  18. Assessment of nucleic acid structure prediction in CASP16.bioRxiv : the preprint server for biology · 2025
    Article
  19. Article
  20. Article

106 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

33 authors.

José Almeida CruzArchitecture et Réactivité de l'ARN, Université de Strasbourg, IBMC-CNRS, F-67084 Strasbourg, France.
Marc-Frédérick Blanchet
Michal Boniecki
Janusz M Bujnicki
Shi-Jie Chen
Song Cao
Rhiju Das
Feng Ding
Nikolay V Dokholyan
Samuel Coulbourn Flores
Lili Huang
Christopher A Lavender
Véronique Lisi
François Major
Katarzyna Mikolajczak
Dinshaw J Patel
Anna Philips
Tomasz Puton
John Santalucia
Fredrick Sijenyi
Thomas Hermann
Kristian Rother
Magdalena Rother
Alexander Serganov
Marcin Skorupski
Tomasz Soltysinski
Parin Sripakdeevong
Irina Tuszynska
Kevin M Weeks
Christina Waldsich
Michael Wildauer
Neocles B Leontis
Eric Westhof

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Nicholas D Socci · 1985 to 2026
$347.4M
Retroviral Genomic RNA Dimer Structure and FunctionR01GM064803 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI WEEKS, KEVIN M · 2002 to 2016
$3.7M
Statistical Mechanics of RNA FoldingR01GM063732 · NIGMS · UNIVERSITY OF MISSOURI-COLUMBIA · PI CHEN, SHI-JIE · 2003 to 2018
$3.2M
Anti-infectives that target bacterial ribosomesU01AI061192 · NIAID · WAYNE STATE UNIVERSITY · PI CUNNINGHAM, PHILIP R · 2004 to 2007
$2.5M
New Antiviral Therapies for Hepatitis C InfectionR01AI072012 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI HERMANN, THOMAS C · 2007 to 2011
$1.8M
Chemotherapy targeting human thymidylate synthase messenger RNAR01CA132753 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI HERMANN, THOMAS C · 2009 to 2013
$1.6M
Software for Structural Bioinformatics of Nucleic AcidR01GM073179 · NIGMS · WAYNE STATE UNIVERSITY · PI SANTALUCIA, JOHN · 2005 to 2008
$1.1M
Software for the accurate de novo 3D structure prediction of RNAR44GM095251 · NIGMS · DNA SOFTWARE, INC. · PI SANTALUCIA, JOHN, SIJENYI, FREDRICK OTIENO · 2010 to 2012
$848k
Software for Homology Modeling of RibosomesR44GM085889 · NIGMS · DNA SOFTWARE, INC. · PI SIJENYI, FREDRICK OTIENO · 2008 to 2010
$819k
Computational prediction of RNA 3D structure using low resolution data and a newR01GM088813 · NIGMS · UNIVERSITY OF MONTREAL · PI MAJOR, FRANCOIS · 2010 to 2014
$778k
Austrian Science Fund FWF P 23497CIHR MOP93679NCI NIH HHS CA132753NCI NIH HHS P30 CA008748NCI NIH HHS R01 CA132753NIAID NIH HHS AI72012NIAID NIH HHS R01 AI072012NIAID NIH HHS U01 AI061192NIAID NIH HHS U01-AI061192NIGMS NIH HHS GM063732NIGMS NIH HHS GM064803NIGMS NIH HHS GM088813NIGMS NIH HHS R01 GM063732NIGMS NIH HHS R01 GM064803NIGMS NIH HHS R01 GM073179NIGMS NIH HHS R01-GM073179NIGMS NIH HHS R01 GM088813NIGMS NIH HHS R44 GM085889NIGMS NIH HHS R44 GM095251NIGMS NIH HHS R44 GM85889
6 · The paper itself

Abstract

We report the results of a first, collective, blind experiment in RNA three-dimensional (3D) structure prediction, encompassing three prediction puzzles. The goals are to assess the leading edge of RNA structure prediction techniques; compare existing methods and tools; and evaluate their relative strengths, weaknesses, and limitations in terms of sequence length and structural complexity. The results should give potential users insight into the suitability of available methods for different applications and facilitate efforts in the RNA structure prediction community in ongoing efforts to improve prediction tools. We also report the creation of an automated evaluation pipeline to facilitate the analysis of future RNA structure prediction exercises.

Indexed as

Nucleic Acid ConformationBase SequenceDimerizationModels, MolecularMolecular Sequence DataRNARNA

Identifiers

PMID22361291
PMCPMC3312550

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.