ArticleMolecular & cellular proteomics : MCP2012
Targeted proteomics of the eicosanoid biosynthetic pathway completes an integrated genomics-proteomics-metabolomics picture of cellular metabolism.
Article in Molecular & cellular proteomics : MCP, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
What it found
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 42 citations in OpenAlex.
- Integrating Multiple Quantitative Proteomic Analyses Using MetaMSD.Methods in molecular biology (Clifton, N.J.) · 2023Pooled it
- Biosynthesis of prostaglandin 15dPGJJournal of lipid research · 2022Article
- SILAC-based quantitative proteomics to investigate the eicosanoid associated inflammatory response in activated macrophages.Journal of inflammation (London, England) · 2022Article
- Functional Characterization of the Cell Division Gene Cluster of the Wall-less BacteriumFrontiers in microbiology · 2021Article
- Quantification of eicosanoids and their metabolites in biological matrices: a review.Bioanalysis · 2018Review
- Tissue proteomics outlines AGR2 AND LOX5 as markers for biochemical recurrence of prostate cancer.Oncotarget · 2018Article
- Application of targeted mass spectrometry in bottom-up proteomics for systems biology research.Journal of proteomics · 2018Review
- Knock-down of AHCY and depletion of adenosine induces DNA damage and cell cycle arrest.Scientific reports · 2018Article
- Liberating Chiral Lipid Mediators, Inflammatory Enzymes, and LIPID MAPS from Biological Grease.The Journal of biological chemistry · 2016Review
- Simultaneous Metabolite, Protein, Lipid Extraction (SIMPLEX): A Combinatorial Multimolecular Omics Approach for Systems Biology.Molecular & cellular proteomics : MCP · 2016Article
- Berberine ameliorates nonbacterial prostatitis via multi-target metabolic network regulation.Omics : a journal of integrative biology · 2015Article
- MOPED 2.5--an integrated multi-omics resource: multi-omics profiling expression database now includes transcriptomics data.Omics : a journal of integrative biology · 2014Article
- Targeted protein quantification using sparse reference labeling.Nature methods · 2014Article
- Modeling of eicosanoid fluxes reveals functional coupling between cyclooxygenases and terminal synthases.Biophysical journal · 2014Article
- A lipidomic perspective on inflammatory macrophage eicosanoid signaling.Advances in biological regulation · 2014Review
- A combined omics study on activated macrophages--enhanced role of STATs in apoptosis, immunity and lipid metabolism.Bioinformatics (Oxford, England) · 2013Article
- Lipidomic profiling of bioactive lipids by mass spectrometry during microbial infections.Seminars in immunology · 2013Review
- Cell metabolomics.Omics : a journal of integrative biology · 2013Review
- Analysis of inflammatory and lipid metabolic networks across RAW264.7 and thioglycolate-elicited macrophages.Journal of lipid research · 2013Article
- Targeted proteomics reveals strain-specific changes in the mouse insulin and central metabolic pathways after a sustained high-fat diet.Molecular systems biology · 2013Article
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 2 countries.
Funding
Abstract
Eicosanoids constitute a diverse class of bioactive lipid mediators that are produced from arachidonic acid and play critical roles in cell signaling and inflammatory aspects of numerous diseases. We have previously quantified eicosanoid metabolite production in RAW264.7 macrophage cells in response to Toll-like receptor 4 signaling and analyzed the levels of transcripts coding for the enzymes involved in the eicosanoid metabolite biosynthetic pathways. We now report the quantification of changes in protein levels under similar experimental conditions in RAW264.7 macrophages by multiple reaction monitoring mass spectrometry, an accurate targeted protein quantification method. The data complete the first fully integrated genomic, proteomic, and metabolomic analysis of the eicosanoid biochemical pathway.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.