Evidence map›Paper›PMID 22361210›Full record

ArticlePsychological medicine2012

Examining variation in depressive symptoms over the life course: a latent class analysis.

B Mezuk, K S Kendler

Open access · greenAbstract readMulticenter Study
In one paragraph

Article in Psychological medicine, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
4.2field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 46 citations in OpenAlex.

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  14. The relationship between major depression and nonsuicide mortality for U.S. adults: the importance of health behaviors.The journals of gerontology. Series B, Psychological sciences and social sciences · 2014
    Article
  15. Latent Classes of Symptoms related to Clinically Depressed Mood in Adolescents.Scandinavian journal of child and adolescent psychiatry and psychology · 2014
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

B MezukDepartment of Epidemiology and Community Health, Virginia Commonwealth University, Richmond, VA 23298, USA. bmezuk@vcu.edu
K S Kendler
Virginia Commonwealth University · US

Funding

VCU Building Interdisciplinary Research Careers in Women's HealthK12HD055881 · NICHD · VIRGINIA COMMONWEALTH UNIVERSITY · PI STRAUSS, JEROME F · 2007 to 2011
$2.5M
NICHD NIH HHS K12 HD055881NICHD NIH HHS K12-HD055881
6 · The paper itself

Abstract

backgroundOlder adults have the lowest prevalence and incidence of major depressive disorder, although it has been hypothesized that this finding is due in part to differences in expression of psychopathology in later life. The aim of this study was to examine variation in depressive symptomatology in the general population across the lifespan.

methodData came from three sites of the Epidemiologic Catchment Area (ECA) Project (n=10 529). Depressive symptoms during the past 6 months were assessed using the Diagnostic Interview Schedule (DIS). Latent class analysis (LCA) was used to identify homogeneous groups of depressive symptomatology based on 16 individual symptoms, and to examine variation in the prevalence and composition of depression classes across age groups.

resultsThe DIS symptoms fit a four-class model composed of non-depressed (83.2%), mild depression (11.6%), severe depression (1.9%), and despondent (3.2%) groups. Relative to the non-depressed class, older age was inversely associated with being in the mild or severe depression class. The profile of the latent classes was similar across age groups with the exception of the despondent class, which was not well differentiated among the youngest adults and was not inversely associated with age.

conclusionsThe symptom profiles of depression are similar across age with the exception of the despondent class, which is more differentiated from severe depression among older adults. The findings demonstrate the benefit of examining individual symptoms rather than broad symptom groups for understanding the natural history of depression over the lifespan.

Indexed as

AdolescentAdultAgedAged, 80 and overAge DistributionAgingDepressive DisorderFemaleGeriatric PsychiatryHumansIncidenceInterview, PsychologicalMaleMiddle AgedPrevalencePsychiatric Status Rating Scales

Identifiers

PMID22361210
PMCPMC3889108
OpenAlexW2149457092

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.