ArticleBiological psychiatry2012
T lymphocytes and vascular inflammation contribute to stress-dependent hypertension.
Article in Biological psychiatry, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.
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Who cites it
51 citing papers in PubMed, 91 citations in OpenAlex.
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- Intersecting epidemics: immune dysregulation associated with HIV and tuberculosis syndemic contribute to increased risk of hypertensive disease in Sub-Saharan Africa.Frontiers in cardiovascular medicine · 2025Review
- Associations of novel blood-derived markers of inflammation with blood pressure, arterial stiffness and heart rate in young adults.Frontiers in cardiovascular medicine · 2025Article
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- Immune and inflammatory mechanisms in hypertension.Nature reviews. Cardiology · 2024Review
- Effects of lifestyle factors on leukocytes in cardiovascular health and disease.Nature reviews. Cardiology · 2024Review
- RUPP Th17s cause hypertension and mitochondrial dysfunction in the kidney and placenta during pregnancy.Pregnancy hypertension · 2023Article
- Microbial bowel infections-induced biochemical and biological abnormalities and their effects on young Egyptian swimmers.Scientific reports · 2023Article
- Neuroimmune axis of cardiovascular control: mechanisms and therapeutic implications.Nature reviews. Cardiology · 2022Review
- Immunity and hypertension: New targets to lighten the pressure.British journal of pharmacology · 2019Article
- β‑estradiol alleviates hypertension‑ and concanavalin A‑mediated inflammatory responses via modulation of connexins in peripheral blood lymphocytes.Molecular medicine reports · 2019Article
- CD8Cytokine · 2019Article
- Environmental Noise-Induced Effects on Stress Hormones, Oxidative Stress, and Vascular Dysfunction: Key Factors in the Relationship between Cerebrocardiovascular and Psychological Disorders.Oxidative medicine and cellular longevity · 2019Review
- A Review of Wearable Solutions for Physiological and Emotional Monitoring for Use by People with Autism Spectrum Disorder and Their Caregivers.Sensors (Basel, Switzerland) · 2018Review
- Age-related arterial immune cell infiltration in mice is attenuated by caloric restriction or voluntary exercise.Experimental gerontology · 2018Article
- Clinical significance of stress-related increase in blood pressure: current evidence in office and out-of-office settings.Hypertension research : official journal of the Japanese Society of Hypertension · 2018Review
- Mechanisms in hypertension and target organ damage: Is the role of the thymus key? (Review).International journal of molecular medicine · 2018Review
- Hydrogen Sulfide Attenuates Hypertensive Inflammation via Regulating Connexin Expression in Spontaneously Hypertensive Rats.Medical science monitor : international medical journal of experimental and clinical research · 2018Article
- Angiotensin II-induced Hypertension is Reduced by Deficiency of P-selectin Glycoprotein Ligand-1.Scientific reports · 2018Article
Corrections and comments
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Authors and funding
7 authors at 5 institutions in 2 countries.
Funding
Abstract
backgroundPsychological stress is a significant risk factor for hypertension and also directly affects the immune system. We have previously reported that T lymphocytes are essential for development of hypertension and that the central nervous system contributes to peripheral T-lymphocyte activation and vascular inflammation in this disease; however, the role of T-cell activation in stress-related hypertension remains unclear.
methodsWild-type and T-cell-deficient (RAG-1(-/-)) mice were subjected to daily episodes of stress and blood pressure was measured. Circulating T-cell activation markers and vascular infiltration of immune cells were analyzed, as were stress hormone levels and gene expression changes in the brain. The effects angiotensin II infusion in the presence of chronic stress was also studied.
resultsRepeated daily stress contributed to acute elevations in blood pressure that were associated with increased activation of circulating T cells and increased vascular infiltration of T cells. Repeated stress increased blood pressure in wild-type but not RAG-1(-/-) mice. Adoptive transfer of T cells to RAG-1(-/-) mice restored blood pressure elevation in response to stress. Stress-related hypertension and vascular infiltration of T cells was markedly enhanced by angiotensin II. Moreover, angiotensin II-infused mice exposed to chronic stress exhibited greater blood pressure reactivity to an episode of acute stress.
conclusionsThese data demonstrate that stress-dependent hypertension triggers an inflammatory response that raises blood pressure at baseline and augments the hypertension caused by angiotensin II. These data provide insight as to how psychological stress contributes to hypertension.
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