ArticleExperimental neurology2012
The lateral thoracic nerve and the cutaneous maximus muscle--a novel in vivo model system for nerve degeneration and regeneration studies.
Article in Experimental neurology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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5 citing papers in PubMed, 10 citations in OpenAlex.
- Spinal circuits encode a map of the trunk to control skin twitches.bioRxiv : the preprint server for biology · 2026Article
- Identification and characterization of a potentially novel dorsal cutaneous muscle in rodents.bioRxiv : the preprint server for biology · 2024Article
- Connecting muscle development, birth defects, and evolution: An essential role for muscle connective tissue.Current topics in developmental biology · 2019Review
- Mechanisms of pruritogen-induced activation of itch nerves in isolated mouse skin.The Journal of physiology · 2017Article
- Length-dependent axo-terminal degeneration at the neuromuscular synapses of type II muscle in SOD1 mice.Neuroscience · 2016Article
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Authors and funding
10 authors at 3 institutions in 2 countries.
Funding
Abstract
We report a novel in vivo mouse model system to study regeneration of injured motor nerve and spatiotemporal pattern of denervation in experimental nerve diseases. The lateral thoracic nerve (LTN), as a pure motor nerve, innervates the cutaneous maximus muscle (CMM) by some of the shortest and the longest motor nerve fibers in the mouse body. Its branches and nerve terminals can be imaged in whole mount preparations. Here we describe the branching pattern of the LTN and its innervation of the CMM, and characterize degeneration and regeneration over time after a LTN crush by morphological and electrophysiological analyses. We demonstrate the utility of this model in a well-established neurotoxicity paradigm and in a genetic disease model of the peripheral neuropathy. Furthermore, this system enables punch biopsies that allow repeated and multi-location examinations for LTN regeneration and CMM reinnervation over time. The presence of the LTN and the CMM in a variety of species and its easy accessibility suggests that this in vivo model system offers considerable promise for future nerve degeneration and regeneration research.
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