Evidence map›Paper›PMID 22360996›Full record

Trial reportCirculation. Cardiovascular imaging2012

Determinants of left ventricular mass in patients on hemodialysis: Frequent Hemodialysis Network (FHN) Trials.

Christopher T Chan, Tom Greene, Glenn M Chertow, Alan S Kliger, John B Stokes, Gerald J Beck, John T Daugirdas, Peter Kotanko, Brett Larive, Nathan W Levin and 7 more

3 registry-linked trialsAbstract readComparative StudyMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Circulation. Cardiovascular imaging, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 40 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00264758 phase2 / phase3completednot on this map

Frequent Hemodialysis Network: Daily Trial

TypeinterventionalSponsorNational Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)Ran2006 to 2010Enrolled245ConditionsEnd Stage Renal DiseaseArmsConventional hemodialysis, Frequent hemodialysis
NCT03759847 nacompletednot on this mapstarted 2019, after this paper: background citation

Fluid Intake App for Management of Volume Intake in Patients Receiving Chronic Hemodialysis Therapy

TypeinterventionalSponsorWake Forest University Health SciencesRan2019 to 2023Enrolled28ConditionsWeight GainArmsFluid intake app, Survey
NCT04194164 nacompletednot on this mapstarted 2019, after this paper: background citation

Fluid Intake App for Management of Volume Intake in Patients Receiving Chronic Hemodialysis Therapy, Full Scale Trial

TypeinterventionalSponsorWake Forest University Health SciencesRan2019 to 2021Enrolled33ConditionsWeight GainArmsFluid intake app
3 · Its place in the literature

Who cites it

40 citing papers in PubMed, 4 syntheses or guidelines pooled it.

  1. Interventions for fatigue in people with kidney failure requiring dialysis.The Cochrane database of systematic reviews · 2023
    Pooled it
  2. Pooled it
  3. Home versus in-centre haemodialysis for end-stage kidney disease.The Cochrane database of systematic reviews · 2014
    Pooled it
  4. Pooled it
  5. Trial
  6. Trial
  7. Trial
  8. BP in Dialysis: Results of a Pilot Study.Journal of the American Society of Nephrology : JASN · 2018
    Trial
  9. Long-term Effects of Frequent Nocturnal Hemodialysis on Mortality: The Frequent Hemodialysis Network (FHN) Nocturnal Trial.American journal of kidney diseases : the official journal of the National Kidney Foundation · 2015
    Trial
  10. Trial
  11. Longitudinal changes in hematocrit in hypertensive chronic kidney disease: results from the African-American Study of Kidney Disease and Hypertension (AASK).Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2015
    Trial
  12. Effects of daily hemodialysis on heart rate variability: results from the Frequent Hemodialysis Network (FHN) Daily Trial.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2014
    Trial
  13. Effects of frequent hemodialysis on ventricular volumes and left ventricular remodeling.Clinical journal of the American Society of Nephrology : CJASN · 2013
    Trial
  14. Trial
  15. Trial
  16. Review
  17. Article
  18. Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Christopher T ChanUniversity Health Network, Ontario, Canada. christopher.chan@uhn.ca
Tom Greene
Glenn M Chertow
Alan S Kliger
John B Stokes
Gerald J Beck
John T Daugirdas
Peter Kotanko
Brett Larive
Nathan W Levin
Ravindra L Mehta
Michael Rocco
Javier Sanz
Brigitte M Schiller
Phillip C Yang
Sanjay Rajagopalan
Frequent Hemodialysis Network (FHN) Trial Group

Funding

Pathways influencing left ventricular hypertrophy in hemodialysis patientsR01DK091288 · NIDDK · UNIVERSITY HEALTH NETWORK · PI CHAN, CHRISTOPHER T · 2011 to 2012
$495k
NIDDK NIH HHS R01 DK091288
6 · The paper itself

Abstract

backgroundAn increase in left ventricular mass (LVM) is associated with mortality and cardiovascular morbidity in patients with end-stage renal disease. METHODS AND

resultsThe Frequent Hemodialysis Network (FHN) Daily Trial randomized 245 patients to 12 months of 6 times per week daily in-center hemodialysis or conventional hemodialysis; the FHN Nocturnal Trial randomized 87 patients to 12 months of 6 times per week nocturnal hemodialysis or conventional hemodialysis. The main cardiac secondary outcome was change in LVM. In each trial, we examined whether several predefined baseline demographic or clinical factors as well as change in volume removal, blood pressure, or solute clearance influenced the effect of frequent hemodialysis on LVM. In the Daily Trial, frequent hemodialysis resulted in a significant reduction in LVM (13.1 g; 95% CI, 5.0-21.3 g; P=0.002), LVM index (6.9 g/m(2); 95% CI, 2.4-11.3 g/m(2); P=0.003), and percent change in geometric mean of LVM (7.0%; 95% CI, 1.0%-12.6; P=0.02). Similar trends were noted in the Nocturnal Trial but did not reach statistical significance. In the Daily Trial, a more pronounced effect of frequent hemodialysis on LVM was evident among patients with left ventricular hypertrophy at baseline. Changes in LVM were associated with changes in blood pressure (conventional hemodialysis: R=0.28, P=0.01, daily hemodialysis: R=0.54, P<0.001) and were not significantly associated with changes in other parameters.

conclusionsFrequent in-center hemodialysis reduces LVM. The benefit of frequent hemodialysis on LVM may be mediated by salutary effects on blood pressure. Clinical Trial Registration- URL: http://www.clinicaltrials.gov. Unique identifier: NCT00264758.

Indexed as

AdultAgedBlood PressureCanadaFemaleHumansHypertrophy, Left VentricularKidney Failure, ChronicLinear ModelsMagnetic Resonance ImagingMaleMiddle AgedProportional Hazards ModelsProspective StudiesRenal DialysisRisk Assessment

Identifiers

PMID22360996
PMCPMC3328963

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.