ArticleBrain injury2012
Mild traumatic brain injury (MTBI) leads to spatial learning deficits.
Article in Brain injury, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 30 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 2 syntheses or guidelines pooled it, 53 citations in OpenAlex.
- Pooled it
- The utilization of small non-mammals in traumatic brain injury research: A systematic review.CNS neuroscience & therapeutics · 2021Pooled it
- The Toll-like receptor 1/2 ligand Pam3Cys inhibits memory impairment after traumatic brain injury in male and female rats.Scientific reports · 2026Article
- Imaging the therapeutic effects of cerebral endothelial cell derived exosome treatment of a preclinical model of Alzheimer's disease.Frontiers in aging neuroscience · 2026Article
- Characterizing Navigational Changes in Preclinical Alzheimer's Disease: A Route Complexity Metric Derived From Naturalistic Driving Data.IEEE journal of translational engineering in health and medicine · 2025Article
- Single Nucleotide Polymorphism in Cell Adhesion Molecule L1 Affects Learning and Memory in a Mouse Model of Traumatic Brain Injury.International journal of molecular sciences · 2024Article
- Effect of stress on the rehabilitation performance of rats with repetitive mild fluid percussion-induced traumatic brain injuries.Cognitive neurodynamics · 2024Article
- Overexpress miR-132 in the Brain Parenchyma by a Non-invasive Way Improves Tissue Repairment and Releases Memory Impairment After Traumatic Brain Injury.Cellular and molecular neurobiology · 2023Article
- Effect of Voluntary Exercise on Endogenous Pain Control Systems and Post-traumatic Headache in Mice.The journal of pain · 2023Article
- A Swine Model of Changes in the Neuronal Electromagnetic Field After Traumatic Brain Injury: A Pilot Study.Cureus · 2023Article
- Inhibition of HIF-1α-AQP4 axis ameliorates brain edema and neurological functional deficits in a rat controlled cortical injury (CCI) model.Scientific reports · 2022Article
- Plasticity impairment alters community structure but permits successful pattern separation in a hippocampal network model.Frontiers in cellular neuroscience · 2022Article
- Potentiating Hemorrhage in a Periadolescent Rat Model of Closed-Head Traumatic Brain Injury Worsens Hyperexcitability but Not Behavioral Deficits.International journal of molecular sciences · 2021Article
- Complement mediates neuroinflammation and cognitive decline at extended chronic time points after traumatic brain injury.Acta neuropathologica communications · 2021Article
- Hyperhomocysteinemia-Induced Oxidative Stress Exacerbates Cortical Traumatic Brain Injury Outcomes in Rats.Cellular and molecular neurobiology · 2021Article
- Cardiac Dysfunction in a Mouse Vascular Dementia Model of Bilateral Common Carotid Artery Stenosis.Frontiers in cardiovascular medicine · 2021Article
- Mechanical injury and blood are drivers of spatial memory deficits after rapid intraventricular hemorrhage.Neurobiology of disease · 2020Article
- Coadministration of Ketamine and Perampanel Improves Behavioral Function and Reduces Inflammation in Acute Traumatic Brain Injury Mouse Model.BioMed research international · 2020Article
- HUCBC Treatment Improves Cognitive Outcome in Rats With Vascular Dementia.Frontiers in aging neuroscience · 2020Article
- Diffuse white matter response in trauma-injured brain to bone marrow stromal cell treatment detected by diffusional kurtosis imaging.Brain research · 2019Article
Corrections and comments
- Erratum issuedDawish, Hala [corrected to Darwish, Hala]
Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
Abstract
PRIMARY
objectiveThe aim of this study was to investigate the effect of mild and severe TBI on young male Wistar rats' spatial learning. RESEARCH
designRandomized repeated measure experimental design was used to examine spatial learning in three independent animal groups. METHODS AND PROCEDURES: Twenty-four (severe n = 9, mild n = 8, sham n = 7) male rats were included in the study. Animals received controlled mild (1.5 mm), severe (2.5 mm) cortical impact injury or sham surgery. Spatial learning was assessed daily using a modified Morris water maze test, 20 days post-trauma, for 5 consecutive days. Percentage time travelled within each quadrant and escape latency were calculated. All animals' hippocampal brain regions were examined post-injury using neuron (MAP2) and pre-synaptic protein (Synaptophysin) biomarkers. MAIN OUTCOMES AND
resultsIt took the animals with mild injury until day 3 to reach the platform; and animals with mild and severe injury spent significantly less time in the target quadrant than the sham. The hippocampal neuron numbers differed proportionately between animals with severe and mild injury, but the percentage of synaptophysin density was significantly less in the dentate gyrus of both animals with mild and severe injury than sham group.
conclusionPersistent spatial learning deficits exist after mild TBI; these deficits appear equivalent to deficits exhibited after a more severe injury.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.