ReviewCurrent medicinal chemistry2012
Current advances in detection and treatment of babesiosis.
Review in Current medicinal chemistry, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 127 papers, 3 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
127 citing papers in PubMed, 3 syntheses or guidelines pooled it, 315 citations in OpenAlex.
- Six Decades of Global Research on Bovine Babesiosis Vaccines: A Comprehensive Systematic Review and Meta-Analysis.Pathogens (Basel, Switzerland) · 2026Pooled it
- Systematic review and meta-regression analysis of the prevalence of tick-borne pathogens in ticks and livestock in Uganda from 1980 to 2024.Scientific reports · 2025Pooled it
- Global prevalence and species diversity of tick-borne pathogens in buffaloes worldwide: a systematic review and meta-analysis.Parasites & vectors · 2023Pooled it
- Treatment Efficacy of Imidocarb Dipropionate in Saanen Goats Experimentally Infected withPathogens (Basel, Switzerland) · 2026Article
- Expression, Purification and Biochemical Characterisation of Babesia bigemina Lactate Dehydrogenase.Molecular biotechnology · 2026Article
- Stalling the Enemy: Targeting Nsp13 for Next-Generation SARS-CoV-2 Antivirals.International journal of molecular sciences · 2026Article
- Persistence and Transmission Dynamics ofPathogens (Basel, Switzerland) · 2025Article
- Furamidine, a methyltransferase inhibitor, is a potential anti-Babesia spp. chemotherapeutic.Parasitology research · 2025Article
- A review of natural products as a source of next-generation drugs against apicomplexan parasites.npj antimicrobials and resistance · 2025Review
- A review of Babesiosis caused by Babesia ovis in small ruminants.Tropical animal health and production · 2025Review
- Article
- Structural and antigenic characterization of Babesia Bovis HAP2 domains.Scientific reports · 2025Article
- Expression and characterization of the immunogenicity of rec-gp45 of Babesia bigemina using cattle.Tropical animal health and production · 2025Article
- Enhanced Anti-Babesia Efficacy of Buparvaquone and Imidocarb When Combined with ELQ-316 In Vitro Culture ofPharmaceuticals (Basel, Switzerland) · 2025Article
- Evaluation of Risk Factors Influencing Tick-Borne Infections in Livestock Through Molecular Analyses.Microorganisms · 2025Article
- Exploring novel inhibitors for Babesia bigemina lactate dehydrogenase: a computational structural biology perspective.Parasitology research · 2025Article
- Development and validation of a real-time SYBR green PCR method for the detection and differentiation of Babesia and Theileria species (Apicomplexa: Piroplasmida) in hard ticks and cattle blood from Thailand.Parasite (Paris, France) · 2025Article
- Development of an colloidal gold immunochromatography assay strip for the diagnosis ofFrontiers in veterinary science · 2025Article
- Efficacy of azithromycin combined with compounded atovaquone in treating babesiosis in giant pandas.Parasites & vectors · 2024Article
- Comparative evaluation of real-time polymerase chain reaction, conventional PCR and microscopy for detection ofJournal of parasitic diseases : official organ of the Indian Society for Parasitology · 2024Article
67 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Babesiosis is a disease with a world-wide distribution affecting many species of mammals principally cattle and man. The major impact occurs in the cattle industry where bovine babesiosis has had a huge economic effect due to loss of meat and beef production of infected animals and death. Nowadays to those costs there must be added the high cost of tick control, disease detection, prevention and treatment. In almost a century and a quarter since the first report of the disease, the truth is: there is no a safe and efficient vaccine available, there are limited chemotherapeutic choices and few low-cost, reliable and fast detection methods. Detection and treatment of babesiosis are important tools to control babesiosis. Microscopy detection methods are still the cheapest and fastest methods used to identify Babesia parasites although their sensitivity and specificity are limited. Newer immunological methods are being developed and they offer faster, more sensitive and more specific options to conventional methods, although the direct immunological diagnoses of parasite antigens in host tissues are still missing. Detection methods based on nucleic acid identification and their amplification are the most sensitive and reliable techniques available today; importantly, most of those methodologies were developed before the genomics and bioinformatics era, which leaves ample room for optimization. For years, babesiosis treatment has been based on the use of very few drugs like imidocarb or diminazene aceturate. Recently, several pharmacological compounds were developed and evaluated, offering new options to control the disease. With the complete sequence of the Babesia bovis genome and the B. bigemina genome project in progress, the post-genomic era brings a new light on the development of diagnosis methods and new chemotherapy targets. In this review, we will present the current advances in detection and treatment of babesiosis in cattle and other animals, with additional reference to several apicomplexan parasites.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.