Evidence map›Paper›PMID 22360307›Full record

ArticleJournal of the American Chemical Society2012

Synthetic polymer nanoparticles conjugated with FimH(A) from E. coli pili to emulate the bacterial mode of epithelial internalization.

Lily Yun Lin, Kristin M Tiemann, Yali Li, Jerome S Pinkner, Jennifer N Walker, Scott J Hultgren, David A Hunstad, Karen L Wooley

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the American Chemical Society, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Urinary Tract Infection: Pathogenesis and Outlook.Trends in molecular medicine · 2016
    Review
  5. Polymer chemistry: Still in control.Nature materials · 2012
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Lily Yun LinDepartment of Chemistry and Chemical Engineering, Texas A&M University, P.O. Box 30012, College Station, Texas 77842, USA.
Kristin M Tiemann
Yali Li
Jerome S Pinkner
Jennifer N Walker
Scott J Hultgren
David A Hunstad
Karen L Wooley

Funding

ADHESIN-BASED NANOTHERAPEUTICS IN URINARY TRACT INFECTIONR01DK082546 · NIDDK · WASHINGTON UNIVERSITY · PI HUNSTAD, DAVID · 2010 to 2014
$1.6M
NIDDK NIH HHS R01 DK082546NIDDK NIH HHS R01-DK082546
6 · The paper itself

Abstract

Amphiphilic block copolymer nanoparticles are conjugated with uropathogenic Escherichia coli type 1 pilus adhesin FimH(A) through amidation chemistry to enable bladder epithelial cell binding and internalization of the nanoparticles in vitro.

Indexed as

Adhesins, Escherichia coliEpithelial CellsEscherichia coliFimbriae ProteinsModels, MolecularNanoparticlesParticle SizePolymersSurface PropertiesAdhesins, Escherichia coliFimbriae ProteinsfimH protein, E coliPolymers

Identifiers

PMID22360307
PMCPMC3325780

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.