ArticleThe Journal of chemical physics2012
Electron stimulated desorption of anions from native and brominated single stranded oligonucleotide trimers.
Article in The Journal of chemical physics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Dissociative Electron Attachment to 8-(Trifluoromethyl)thioadenine: A Potential Radiosensitizer.The journal of physical chemistry. B · 2026Article
- Substituted benzylamino-2'-deoxyadenosine a modified nucleoside with radiosensitizing properties.Scientific reports · 2025Article
- Surprising Radiolytic Stability of 8-Thiomethyladenine in an Aqueous Solution.The journal of physical chemistry. B · 2024Article
- 5-(International journal of molecular sciences · 2020Article
- Uracil-5-ylThe journal of physical chemistry. B · 2020Article
- Why Does the Type of Halogen Atom Matter for the Radiosensitizing Properties of 5-Halogen Substituted 4-Thio-2'-Deoxyuridines?Molecules (Basel, Switzerland) · 2019Article
- Dissociative electron attachment to DNA-diamine thin films: impact of the DNA close environment on the OH- and O- decay channels.The Journal of chemical physics · 2013Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
We measured the low energy electron stimulated desorption (ESD) of anions from thin films of native (TXT) and bromine monosubstituted (TBrXT) oligonucleotide trimers deposited on a gold surface (T = thymidine, X = T, deoxycytidine (C), deoxyadenosine (A) or deoxyguanosine (G), Br = bromine). The desorption of H(-), CH(3)(-)/NH(-), O(-)/NH(2)(-), OH(-), CN(-), and Br(-) was induced by 0 to 20 eV electrons. Dissociative electron attachment, below 12 eV, and dipolar dissociation, above 12 eV, are responsible for the formation of these anions. The comparison of the results obtained for the native and brominated trimers suggests that the main pathways of TBrXT degradation correspond to the release of the hydride and bromide anions. Significantly, the presence of bromine in oligonucleotide trimers blocks the electron-induced degradation of nuclobases as evidenced by a dramatic decrease in CN(-) desorption. An increase in the yields of OH(-) is also observed. The debromination yield of particular oligonucleotides diminishes in the following order: BrdU > BrdA > BrdG > BrdC. Based on these results, 5-bromo-2(')-deoxyuridine appears to be the best radiosensitizer among the studied bromonucleosides.
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