ArticlePloS one2012
S phase entry of neural progenitor cells correlates with increased blood flow in the young subventricular zone.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.
- Pooled it
- 3D Image Analysis of the Complete Ventricular-Subventricular Zone Stem Cell Niche Reveals Significant Vasculature Changes and Progenitor Deficits in Males Versus Females with Aging.Stem cell reports · 2021Article
- Bioengineering the neurovascular niche to study the interaction of neural stem cells and endothelial cells.APL bioengineering · 2021Review
- Pharmacological Stimulation of Nurr1 Promotes Cell Cycle Progression in Adult Hippocampal Neural Stem Cells.International journal of molecular sciences · 2019Article
- Role of mTOR Complexes in Neurogenesis.International journal of molecular sciences · 2018Review
- FACS isolation of endothelial cells and pericytes from mouse brain microregions.Nature protocols · 2018Article
- Multifaceted Roles of Connexin 43 in Stem Cell Niches.Current stem cell reports · 2018Review
- Cerebral blood flow regulation and neurovascular dysfunction in Alzheimer disease.Nature reviews. Neuroscience · 2017Review
- How Necessary is the Vasculature in the Life of Neural Stem and Progenitor Cells? Evidence from Evolution, Development and the Adult Nervous System.Frontiers in cellular neuroscience · 2016Article
- Astrocyte regulation of blood flow in the brain.Cold Spring Harbor perspectives in biology · 2015Review
- Regional and stage-specific effects of prospectively purified vascular cells on the adult V-SVZ neural stem cell lineage.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- NTPDase2 and purinergic signaling control progenitor cell proliferation in neurogenic niches of the adult mouse brain.Stem cells (Dayton, Ohio) · 2015Article
- Regulation of blood flow in the retinal trilaminar vascular network.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Epigenetic regulation of adult neural stem cells: implications for Alzheimer's disease.Molecular neurodegeneration · 2014Review
- Vascular regulation of adult neurogenesis under physiological and pathological conditions.Frontiers in neuroscience · 2014Review
- Novel pathological features and potential therapeutic approaches for CADASIL: insights obtained from a mouse model of CADASIL.Therapeutic targets for neurological diseases · 2014Article
- GABAergic striatal neurons project dendrites and axons into the postnatal subventricular zone leading to calcium activity.Frontiers in cellular neuroscience · 2014Article
- Vascular niche for astrocyte proliferation: limited and in situ.CNS neuroscience & therapeutics · 2013Article
- Delineating multiple functions of VEGF-A in the adult brain.Cellular and molecular life sciences : CMLS · 2013Review
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
The postnatal subventricular zone (SVZ) contains proliferating neural progenitor cells in close proximity to blood vessels. Insults and drug treatments acutely stimulate cell proliferation in the SVZ, which was assessed by labeling cells entering S phase. Although G1-to-S progression is metabolically demanding on a minute-to-hour time scale, it remains unknown whether increased SVZ cell proliferation is accompanied by a local hemodynamic response. This neurovascular coupling provides energy substrates to active neuronal assemblies. Transcardial dye perfusion revealed the presence of capillaries throughout the SVZ that constrict upon applications of the thromboxane A(2) receptor agonist U-46119 in acute brain slice preparations. We then monitored in vivo blood flow using laser Doppler flowmetry via a microprobe located either in the SVZ or a mature network. U-46119 injections into the lateral ventricle decreased blood flow in the SVZ and the striatum, which are near the ventricle. A 1-hour ventricular injection of epidermal and basic fibroblast growth factor (EGF and bFGF) significantly increased the percentage of Sox2 transcription factor-positive cells in S phase 1.5 hours post-injection. This increase was accompanied by a sustained rise in blood flow in the SVZ but not in the striatum. Direct growth factor injections into the cortex did not alter local blood flow, ruling out direct effects on capillaries. These findings suggest that an acute increase in the number of G1-to-S cycling SVZ cells is accompanied by neurometabolic-vascular coupling, which may provide energy and nutrient for cell cycle progression.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.