ArticlePLoS genetics2012
A strong deletion bias in nonallelic gene conversion.
Article in PLoS genetics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- The impact of poly-A microsatellite heterologies in meiotic recombination.Life science alliance · 2019Article
- Molecular Population Genetics.Genetics · 2017Review
- The rate of meiotic gene conversion varies by sex and age.Nature genetics · 2016Article
- History of plastid DNA insertions reveals weak deletion and at mutation biases in angiosperm mitochondrial genomes.Genome biology and evolution · 2014Article
- Natural variation in genome architecture among 205 Drosophila melanogaster Genetic Reference Panel lines.Genome research · 2014Article
- Architecture and evolution of a minute plant genome.Nature · 2013Article
- Article
- Hard selective sweep and ectopic gene conversion in a gene cluster affording environmental adaptation.PLoS genetics · 2013Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Gene conversion is the unidirectional transfer of genetic information between orthologous (allelic) or paralogous (nonallelic) genomic segments. Though a number of studies have examined nucleotide replacements, little is known about length difference mutations produced by gene conversion. Here, we investigate insertions and deletions produced by nonallelic gene conversion in 338 Drosophila and 10,149 primate paralogs. Using a direct phylogenetic approach, we identify 179 insertions and 614 deletions in Drosophila paralogs, and 132 insertions and 455 deletions in primate paralogs. Thus, nonallelic gene conversion is strongly deletion-biased in both lineages, with almost 3.5 times as many conversion-induced deletions as insertions. In primates, the deletion bias is considerably stronger for long indels and, in both lineages, the per-site rate of gene conversion is orders of magnitudes higher than that of ordinary mutation. Due to this high rate, deletion-biased nonallelic gene conversion plays a key role in genome size evolution, leading to the cooperative shrinkage and eventual disappearance of selectively neutral paralogs.
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Registered trials
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