ArticleThe Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology2011
Chronic Opium Treatment Can Differentially Induce Brain and Liver Cells Apoptosis in Diabetic and Non-diabetic Male and Female Rats.
Article in The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.
- Opium abuse and stroke in Iran: A systematic review and meta-analysis.Frontiers in neurology · 2022Pooled it
- The effect of opium consumption on prostate cancer among Iranian patients: A retrospective analytical study.Medicine · 2026Article
- Evaluation of the Effects of Opium on the Expression ofBladder cancer (Amsterdam, Netherlands) · 2024Article
- The Impact of Diabetes Mellitus in COVID-19: A Mechanistic Review of Molecular Interactions.Journal of diabetes research · 2020Review
- Update of the Scientific Opinion on opium alkaloids in poppy seeds.EFSA journal. European Food Safety Authority · 2018Article
- Effects of Opium Addiction on Some Biochemical Factors in Diabetic Rats.Addiction & health · 2018Article
- Opium induces apoptosis in Jurkat cells via promotion of pro-apoptotic and inhibition of anti-apoptotic molecules.Iranian journal of basic medical sciences · 2016Article
- Effect of intravenous patient controlled ketamine analgesiaon postoperative pain in opium abusers.Anesthesiology and pain medicine · 2014Article
- Ovary cells apoptosis in opium-addicted diabetic and non-diabetic rats.International journal of high risk behaviors & addiction · 2013Article
- Hematological changes in opium addicted diabetic rats.International journal of high risk behaviors & addiction · 2013Article
- THE EFFECTS OF OPIUM ADDICTION ON THYROID AND SEX HORMONES IN DIABETIC AND NON-DIABETIC MALE AND FEMALE RATS.Acta endocrinologica (Bucharest, Romania : 2005)Article
- Opium induces apoptosis in jurkat cells.Addiction & healthArticle
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
It has been shown that some opium derivatives promote cell death via apoptosis. This study was designed to examine the influence of opium addiction on brain and liver cells apoptosis in male and female diabetic and non-diabetic Wistar rats. This experimental study was performed on normal, opium-addicted, diabetic and diabetic opium-addicted male and female rats. Apoptosis was evaluated by TUNEL and DNA fragmentation assays. Results of this study showed that apoptosis in opium-addicted and diabetic opium-addicted brain and liver cells were significantly higher than the both normal and diabetic rats. In addition, we found that apoptosis in brain cells of opium-addicted and diabetic opium-addicted male rats were significantly higher than opium-addicted and diabetic opium-addicted female, whereas apoptosis in liver cells of opium-addicted and diabetic opium-addicted female rats were significantly higher than opium-addicted and diabetic opium-addicted male. Overall, these results indicate that opium probably plays an important role in brain and liver cells apoptosis, therefore, leading neurotoxicity and hepatotoxicity. These findings also in away possibly means that male brain cells are more susceptible than female and interestingly liver of females are more sensitive than males in induction of apoptosis by opium.
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