ReviewCurrent rheumatology reports2012
Current understanding of the pathogenesis and management of chronic recurrent multifocal osteomyelitis.
Review in Current rheumatology reports, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 71 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
71 citing papers in PubMed, 190 citations in OpenAlex.
- Acute phase reactants in paediatric chronic nonbacterial osteomyelitis: implications for diagnosis and correlation with disease phenotype.Rheumatology (Oxford, England) · 2026Article
- How Organ Manifestations Beyond the Bone May Guide Risk Stratification and Treatment Decisions in Chronic Nonbacterial Osteomyelitis.Paediatric drugs · 2026Review
- A novelLife science alliance · 2026Article
- A Rare Occurrence of Chronic Recurrent Multifocal Osteomyelitis in Clavicle: Case Report.Journal of orthopaedic case reports · 2026Article
- Limb-Sparing Reconstruction for Chronic Non-Bacterial Osteomyelitis of the Toe in a Pediatric Athlete: A Case Report.Reports (MDPI) · 2026Article
- Chronic nonbacterial osteomyelitis: a typical case and review.Frontiers in pediatrics · 2026Review
- Chronic Non-Bacterial Osteomyelitis in Pediatric Patients: Findings from Multiple Centers in Saudi Arabia.Journal of epidemiology and global health · 2025Article
- Review
- Chronic Nonbacterial Osteomyelitis in a Young Child: A Case Report of a Diagnostic Challenge Mimicking Malignancy.Cureus · 2025Article
- Article
- Chronic Non-Bacterial Osteomyelitis (CNO) in a Tertiary Center in Southern Italy: Response to Treatment and Outcome Stratification.Children (Basel, Switzerland) · 2025Article
- What Is New and What Is Next for SAPHO Syndrome Management: A Narrative Review.Journal of clinical medicine · 2025Review
- Factors associated with treatment response in chronic nonbacterial osteomyelitis at a single center: a retrospective cohort study.Pediatric rheumatology online journal · 2025Article
- Autoinflammatory Bone Diseases.Balkan medical journal · 2025Review
- SAPHO syndrome: current clinical, diagnostic and treatment approaches.Rheumatology international · 2024Review
- Article
- Not just sugar: metabolic control of neutrophil development and effector functions.Journal of leukocyte biology · 2024Review
- Pediatric mandibular chronic nonbacterial osteomyelitis: A case report with 12 years of radiologic follow-up.Imaging science in dentistry · 2024Article
- Adult-onset chronic recurrent multifocal osteomyelitis: a case report.Skeletal radiology · 2024Article
- Review
11 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Chronic recurrent multifocal osteomyelitis (CRMO) is an inflammatory disorder that primarily affects children. Its hallmark is recurring episodes of sterile osteomyelitis. The clinical presentation is insidious onset of bone pain with or without fever. Laboratory studies typically reveal nonspecific evidence of inflammation. Radiologic imaging and histologic appearance resemble those of infectious osteomyelitis. There is a strong association with inflammatory disorders of the skin and intestinal tract in affected individuals and their close relatives, suggesting a shared pathophysiology and supporting a genetic component to disease susceptibility. Two genetic syndromes have CRMO as a prominent phenotype-Majeed syndrome and deficiency of the interleukin-1 receptor antagonist-and suggest that interleukin-1 may be a key cytokine in disease pathogenesis. This review briefly summarizes the main clinical and radiologic aspects of the disease and then focuses on genetics and pathophysiology and provides an update on treatment.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.