ReviewNeuropsychology review2012
Family history and APOE-4 genetic risk in Alzheimer's disease.
Review in Neuropsychology review, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
37 citing papers in PubMed, 1 synthesis or guideline pooled it, 75 citations in OpenAlex.
- Androgen Deprivation Therapy Unrelated to Alzheimer's Disease in the UK Biobank Cohort.Anticancer research · 2023Pooled it
- Potential biases associated with reported parental history of dementia in the Alzheimer's Disease Research Center cohorts: Implications for secondary data analyses.Journal of Alzheimer's disease : JAD · 2026Article
- Dynamic functional connectivity is modulated by the amount of p-Tau231 in blood in cognitively intact participants.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2025Article
- Factors related to blood-based biomarkers for neurodegenerative diseases and their intergenerational associations in the Young Finns Study: a cohort study.The lancet. Healthy longevity · 2025Article
- Precuneus Activity during Retrieval Is Positively Associated with Amyloid Burden in Cognitively Normal OlderThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Uncovering atrophy progression pattern and mechanisms in individuals at risk of Alzheimer's disease.Brain communications · 2025Article
- APOE4-related differences in cortical thickness are modulated by sex in middle age.Brain imaging and behavior · 2024Article
- Longitudinal changes in the functional connectivity of individuals at risk of Alzheimer's disease.GeroScience · 2024Article
- Dynamic functional connectivity is modulated by the amount of p-Tau231 in blood in cognitively intact participants.bioRxiv : the preprint server for biology · 2024Article
- Subjective Cognitive Decline and Genetic Propensity for Dementia beyond Apolipoprotein εCurrent issues in molecular biology · 2024Review
- Alzheimer's disease: a comprehensive review of epidemiology, risk factors, symptoms diagnosis, management, caregiving, advanced treatments and associated challenges.Frontiers in medicine · 2024Review
- Minimum spanning tree analysis of unimpaired individuals at risk of Alzheimer's disease.Brain communications · 2024Article
- Therapeutic Inhalation of Hydrogen Gas for Alzheimer's Disease Patients and Subsequent Long-Term Follow-Up as a Disease-Modifying Treatment: An Open Label Pilot Study.Pharmaceuticals (Basel, Switzerland) · 2023Article
- Early visual alterations in individuals at-risk of Alzheimer's disease: a multidisciplinary approach.Alzheimer's research & therapy · 2023Article
- Retinal Vascular Study Using OCTA in Subjects at High Genetic Risk of Developing Alzheimer's Disease and Cardiovascular Risk Factors.Journal of clinical medicine · 2022Article
- Article
- Interaction between genetic predisposition, smoking, and dementia risk: a population-based cohort study.Scientific reports · 2021Article
- Foveal Avascular Zone and Choroidal Thickness Are Decreased in Subjects with Hard Drusen and without High Genetic Risk of Developing Alzheimer's Disease.Biomedicines · 2021Article
- Genetic test for the personalization of sport training.Acta bio-medica : Atenei Parmensis · 2020Review
- Association between anti-inflammatory interleukin-10 and executive function in African American women at risk for Alzheimer's disease.Journal of clinical and experimental neuropsychology · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 3 countries.
Funding
Abstract
Identifying risk factors for Alzheimer's disease, such as carrying the APOE-4 allele, and understanding their contributions to disease pathophysiology or clinical presentation is critical for establishing and improving diagnostic and therapeutic strategies. A first-degree family history of Alzheimer's disease represents a composite risk factor, which reflects the influence of known and unknown susceptibility genes and perhaps non-genetic risks. There is emerging evidence that investigating family history risk associated effects may contribute to advances in Alzheimer's disease research and ultimately clinical practice.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.