ArticleNeurochemical research2012
Plasma membrane-associated glycohydrolases activation by extracellular acidification due to proton exchangers.
Article in Neurochemical research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 16 citations in OpenAlex.
- Forgotten Gangliosides:International journal of molecular sciences · 2026Review
- Gangliosides and Cell Surface Ganglioside Metabolic Enzymes in the Nervous System.Advances in neurobiology · 2023Article
- Proceedings of workshop: "Neuroglycoproteins in health and disease", INNOGLY cost action.Glycoconjugate journal · 2022Article
- The structure of gangliosides hides a code for determining neuronal functions.FEBS open bio · 2021Review
- Sphingolipids and plasma membrane hydrolases in human primary bronchial cells during differentiation and their altered patterns in cystic fibrosis.Glycoconjugate journal · 2020Article
- Biochemical Characterization of theInternational journal of molecular sciences · 2018Article
- Neuronal membrane dynamics as fine regulator of sphingolipid composition.Glycoconjugate journal · 2018Review
- Current and Novel Aspects on the Non-lysosomal β-Glucosylceramidase GBA2.Neurochemical research · 2016Review
- Lipid rafts in neurodegeneration and neuroprotection.Molecular neurobiology · 2014Review
- GBA2-encoded β-glucosidase activity is involved in the inflammatory response to Pseudomonas aeruginosa.PloS one · 2014Article
- Ionizing radiations increase the activity of the cell surface glycohydrolases and the plasma membrane ceramide content.Glycoconjugate journal · 2012Article
- Plasma membrane-associated glycohydrolases along differentiation of murine neural stem cells.Neurochemical research · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In this paper, we show that the pH optimum for the plasma membrane (PM)-associated activity of four glycohydrolases (conduritol B epoxide sensitive β-glucosidase, β-glucosidase GBA2, β-hexosaminidase and β-galactosidase) measured on intact cells is acidic. Moreover, we show that drugs able to modify the efflux of protons across the PM, thus locally affecting the extracellular proton concentration close to the PM, are able to modulate the activities of these enzymes. These data strongly suggest that pH-dependent modulation of PM-associated glycohydrolases activities could be an effective way to locally modulate the cell surface glycoconjugate composition.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.