ArticleCytotechnology1987
c-Fos protooncogene expression in human normal peripheral blood leukocytes.
Article in Cytotechnology, 1987. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aim of this study was to investigate the expression of c-fos protooncogene in normal human peripheral blood leukocytes by Northern blot analysis. Unlike lymphoid cells, monocytes express appreciable levels of c-fos transcripts. Unexpectedly, unlike HL-60 (promyelocytic)-derived granulocytes, freshly isolated polymorphonuclear cells (PMN) showed c-fos expression, with higher levels of expression then monocytes. The expression of c-fos by PMN was superinduced by cycloheximide. When PMN were treated with stimuli known to activate some functional activities of these cells (phorbol esters, inactivated streptococci, colony-stimulating factors, tumor necrosis factor) the expression of c-fos was augmented. The 'constitutive' and inducible expression of c-fos in PMN was also detectable after 20 hours of culture. These data show that, among the cells belonging to the myelo-monocytic lineage, c-fos expression is not restricted to monocytes-macrophages and that data obtained from established cell lines are not necessarily representative of fresh normal cells. c-fos expression in PMN may play a role in the regulation of mature circulating myelocytes.
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