ArticlePediatric nephrology (Berlin, Germany)2012
Early cardiac dysfunction in pediatric patients on maintenance dialysis and post kidney transplant.
Article in Pediatric nephrology (Berlin, Germany), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 27 citations in OpenAlex.
- Arginine Dysregulation and Myocardial Dysfunction in a Mouse Model and Children with Chronic Kidney Disease.Nutrients · 2023Article
- Cardiovascular effects of metabolic syndrome after transplantation: convergence of obesity and transplant-related factors.Clinical kidney journal · 2018Article
- A novel ultrasound technique to detect early chronic kidney disease.F1000Research · 2018Article
- Longitudinal assessment of myocardial function in childhood chronic kidney disease, during dialysis, and following kidney transplantation.Pediatric nephrology (Berlin, Germany) · 2017Article
- Left Ventricular Hypertrophy in Pediatric Hypertension: A Mini Review.Frontiers in pediatrics · 2017Review
- Assessment of Left Ventricular Mass and Hypertrophy by Cardiovascular Magnetic Resonance Imaging in Pediatric Hypertension.Journal of clinical hypertension (Greenwich, Conn.) · 2016Observational
- Left ventricular mass and systolic function in children with chronic kidney disease-comparing echocardiography with cardiac magnetic resonance imaging.Pediatric nephrology (Berlin, Germany) · 2016Article
- Left ventricular mass and cardiac function in a population of children with chronic kidney disease.Pediatric nephrology (Berlin, Germany) · 2014Article
- Myocardial Ischemia Assessment in Chronic Kidney Disease: Challenges and Pitfalls.Frontiers in cardiovascular medicine · 2014Review
- BP control and left ventricular hypertrophy regression in children with CKD.Journal of the American Society of Nephrology : JASN · 2014Article
- Cardiac dysfunction in pediatric patients on renal replacement therapy.Pediatric nephrology (Berlin, Germany) · 2012Article
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6 authors at 1 institution in 1 country.
Funding
Abstract
backgroundChildren with advanced chronic kidney disease (CKD) frequently develop left ventricular (LV) hypertrophy. The extent of hypertrophy that results in cardiac dysfunction is unknown. Systolic function, routinely determined by ejection fraction (EF), is usually preserved in these patients. However, a decrease in EF represents an advanced cardiac dysfunction. We used cardiac magnetic resonance (CMR) and phosphorus-31 MR spectroscopy (31P MRS) to assess markers of cardiac dysfunction in young CKD patients.
methodsTen dialysis and ten post-transplant patients completed the study. The outcomes were peak LV myocardial circumferential strain (Ecc); myocardial T2 relaxation time and full width at half maximum (FWHM) of T2 distribution; and phosphocreatinine/adenosine triphosphate (PCr/ATP) to measure muscle energy metabolism. Healthy controls were used for comparison.
resultsAll patients had normal EF; nine (45%) had low Ecc. Ecc was lower in dialysis versus transplant (p<0.0001) patients and inversely correlated with LV mass index, r= -0.47, p=0.04. Patients had higher T2 (p=0.056) and FWHM (p=0.01) than controls. T2 levels were positively correlated with LVM index (r=0.46, p=0.04). PCr/ATP was lower in patients than in controls (p=0.02).
conclusionYoung patients with advanced CKD and normal EF have early cardiac changes. Association of these abnormalities with increased left ventricular mass (LVM) index suggests development of maladaptive hypertrophy.
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