ArticleJournal of neural transmission (Vienna, Austria : 1996)2012
Social behavior impairment in offspring exposed to maternal seizures in utero.
Article in Journal of neural transmission (Vienna, Austria : 1996), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
8 citing papers in PubMed, 13 citations in OpenAlex.
- Issues of Women with Epilepsy and Suitable Antiseizure Drugs.Journal of epilepsy research · 2023Review
- Multisensory Stimulation Reverses Memory Impairment in AdrβInternational journal of molecular sciences · 2023Article
- Long-term obesity is associated with depression and neuroinflammation.Archives of endocrinology and metabolism · 2021Article
- Increased Endocannabinoid Signaling Reduces Social Motivation in Intact Rats and Does Not Affect Animals Submitted to Early-Life Seizures.Frontiers in behavioral neuroscience · 2020Article
- Effect of diazepam on sociability of rats submitted to neonatal seizures.Data in brief · 2016Article
- Early life seizures in female rats lead to anxiety-related behavior and abnormal social behavior characterized by reduced motivation to novelty and deficit in social discrimination.Journal of neural transmission (Vienna, Austria : 1996) · 2015Article
- Sex and hormonal influences on seizures and epilepsy.Hormones and behavior · 2013Review
- Altered anxiety-related and abnormal social behaviors in rats exposed to early life seizures.Frontiers in behavioral neuroscience · 2013Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Human and animal models have demonstrated that maternal seizures in utero could be deleterious to the development of the offspring. This study focused on the social behavior of offspring exposed to seizures in utero. A pilocarpine model of temporal lobe epilepsy was induced in female Wistar rats that were mated after the first spontaneous seizure. Early after birth, pups from an epileptic mother were reared by a control mother. To evaluate the influence of the adoption process, two other groups were added: rat pups from control mothers cross-fostered with other control mothers, and rat pups reared by their birth mother. Animals exposed to seizures in utero showed impaired social behavior with no signs of anxiety-like behavior. This study demonstrated that epileptic seizures during pregnancy could be harmful to brain development and may increase the risk of developing neurodevelopmental disorders. The mechanisms underlying the abnormalities of social behavior are not well understood, and further studies in this field are warranted.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.