Trial reportDiabetes2012
Salicylate downregulates 11β-HSD1 expression in adipose tissue in obese mice and in humans, mediating insulin sensitization.
Trial report in Diabetes, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 63 citations in OpenAlex.
- Diet-induced weight loss alters hepatic glucocorticoid metabolism in type 2 diabetes mellitus.European journal of endocrinology · 2020Trial
- Diet-induced weight loss has chronic tissue-specific effects on glucocorticoid metabolism in overweight postmenopausal women.International journal of obesity (2005) · 2015Trial
- Salsalate treatment improves glycemia without altering adipose tissue in nondiabetic obese hispanics.Obesity (Silver Spring, Md.) · 2015Trial
- Targeting inflammation using salsalate in patients with type 2 diabetes: effects on flow-mediated dilation (TINSAL-FMD).Diabetes care · 2013Trial
- Salicylate (salsalate) in patients with type 2 diabetes: a randomized trial.Annals of internal medicine · 2013Trial
- A randomised trial of salsalate for insulin resistance and cardiovascular risk factors in persons with abnormal glucose tolerance.Diabetologia · 2013Trial
- Linking the degree of intrauterine growth restriction to alterations in metabolism, energy reserves, and gut health in newborn piglets.Journal of animal science · 2026Article
- The Ancient Drug Salicylate Indirectly Targets Fructose-1,6-Bisphosphatase to Suppress Liver Glucose Production in Diet-Induced Obese Mice.Acta physiologica (Oxford, England) · 2025Article
- Sodium salicylate ameliorates exercise-induced muscle damage in mice by inhibiting NF-kB signaling.Journal of orthopaedic surgery and research · 2023Article
- Effects of very low-calorie ketogenic diet on hypothalamic-pituitary-adrenal axis and renin-angiotensin-aldosterone system.Journal of endocrinological investigation · 2023Review
- What's gut got to do with it? The role of the microbiota and inflammation in the development of adiposity and obesity.Immunometabolism (Cobham, Surrey) · 2023Review
- Body weight of newborn and suckling piglets affects their intestinal gene expression.Journal of animal science · 2022Article
- Carbonyl reductase 1 amplifies glucocorticoid action in adipose tissue and impairs glucose tolerance in lean mice.Molecular metabolism · 2021Article
- Article
- Salsalate Prevents β-Cell Dedifferentiation in OLETF Rats with Type 2 Diabetes through Notch1 Pathway.Aging and disease · 2019Article
- 11Beta-hydroxysteroid dehydrogenase-1 deficiency or inhibition enhances hepatic myofibroblast activation in murine liver fibrosis.Hepatology (Baltimore, Md.) · 2018Article
- 11β-Hydroxysteroid Dehydrogenase Type 1(11β-HSD1) mediates insulin resistance through JNK activation in adipocytes.Scientific reports · 2016Article
- Oxylipid Profile of Low-Dose Aspirin Exposure: A Pharmacometabolomics Study.Journal of the American Heart Association · 2015Article
- Glucocorticoid receptor gene expression in adipose tissue and associated metabolic risk in black and white South African women.International journal of obesity (2005) · 2015Article
- Tissue-specific dysregulation of cortisol regeneration by 11βHSD1 in obesity: has it promised too much?Diabetologia · 2014Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
Recent trials show salicylates improve glycemic control in type 2 diabetes, but the mechanism is poorly understood. Expression of the glucocorticoid-generating enzyme 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) in adipose tissue is increased in vitro by proinflammatory cytokines and upregulated in obesity. 11β-HSD1 inhibition enhances insulin sensitivity. We hypothesized that salicylates downregulate 11β-HSD1 expression, contributing to their metabolic efficacy. We treated diet-induced obese (DIO) 11β-HSD1-deficient mice and C57Bl/6 mice with sodium salicylate for 4 weeks. Glucose tolerance was assessed in vivo. Tissue transcript levels were assessed by quantitative PCR and enzyme activity by incubation with (3)H-steroid. Two weeks' administration of salsalate was also investigated in a randomized double-blind placebo-controlled crossover study in 16 men, with measurement of liver 11β-HSD1 activity in vivo and adipose tissue 11β-HSD1 transcript levels ex vivo. In C57Bl/6 DIO mice, salicylate improved glucose tolerance and downregulated 11β-HSD1 mRNA and activity selectively in visceral adipose. DIO 11β-HSD1-deficient mice were resistant to these metabolic effects of salicylate. In men, salsalate reduced 11β-HSD1 expression in subcutaneous adipose, and in vitro salicylate treatment reduced adipocyte 11β-HSD1 expression and induced adiponectin expression only in the presence of 11β-HSD1 substrate. Reduced intra-adipose glucocorticoid regeneration by 11β-HSD1 is a novel mechanism that contributes to the metabolic efficacy of salicylates.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.