ArticleAmerican journal of physiology. Renal physiology2012
Effects of ibuprofen treatment on the developing preterm baboon kidney.
Article in American journal of physiology. Renal physiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 53 citations in OpenAlex.
- Kidney care at NICU discharge and follow-up recommendations for preterm infants<34 weeks.Journal of perinatology : official journal of the California Perinatal Association · 2026Article
- Prenatal NSAIDs exposure and childhood kidney disease: a systematic review and meta-analysis.Frontiers in pediatrics · 2026Review
- Insulin-like growth factor-1 effects on kidney development in preterm piglets.Pediatric research · 2024Article
- Human Nephrogenesis can Persist Beyond 40 Postnatal Days in Preterm Infants.Kidney international reports · 2024Article
- Blood Pressure Outcomes in NICU-Admitted Infants with Neonatal Hypertension: A Pediatric Nephrology Research Consortium Study.The Journal of pediatrics · 2024Article
- The impact of intrauterine growth restriction and prematurity on nephron endowment.Nature reviews. Nephrology · 2023Review
- Nonsteroidal anti-inflammatory drugs and implications for the cyclooxygenase pathway in embryonic development.American journal of physiology. Cell physiology · 2023Review
- Regulation of nephron progenitor cell lifespan and nephron endowment.Nature reviews. Nephrology · 2022Review
- Preterm birth and neonatal acute kidney injury: implications on adolescent and adult outcomes.Journal of perinatology : official journal of the California Perinatal Association · 2020Review
- Late Acetaminophen Therapy for Patent Ductus Arteriosus in the Preterm Neonate.The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG · 2020Article
- [Monitoring of kidney injury in preterm infants].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2018Review
- Acetylsalicylic acid interferes with embryonic kidney growth and development by a prostaglandin-independent mechanism.World journal of nephrology · 2017Article
- Article
- Effects of preterm birth and ventilation on glomerular capillary growth in the neonatal lamb kidney.Journal of hypertension · 2016Article
- Each niche has an actor: multiple stem cell niches in the preterm kidney.Italian journal of pediatrics · 2015Review
- Drug-induced renal damage in preterm neonates: state of the art and methods for early detection.Drug safety · 2015Review
- Animal models of bronchopulmonary dysplasia. The preterm baboon models.American journal of physiology. Lung cellular and molecular physiology · 2014Review
- Nephron number and its determinants in early life: a primer.Pediatric nephrology (Berlin, Germany) · 2014Review
- The interplay between drugs and the kidney in premature neonates.Pediatric nephrology (Berlin, Germany) · 2014Review
- Impaired renal function and development in Belgrade rats.American journal of physiology. Renal physiology · 2014Article
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Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Preterm neonates are commonly exposed postnatally to pharmacological treatments for a patent ductus arteriosus. Exposure of the developing kidney to nephrotoxic medications may adversely impact renal development. This study aimed to determine the effect of early postnatal ibuprofen treatment, both alone and in combination with a nitric oxide synthase inhibitor (NOSi), on renal development and morphology. Baboon neonates were delivered prematurely at 125-day (125d) gestation (term = 185d) and were euthanized at birth or postnatal day 6. Neonates were divided into four groups: 125d gestational controls (n = 8), Untreated (n = 8), Ibuprofen (n = 6), and ibuprofen (Ibu)+NOSi (n = 4). Animals in the Ibuprofen and Ibu+NOSi groups received five doses of ibuprofen, with the Ibuprofen+NOSi animals additionally administered a NOS inhibitor (N(G)-monomethyl-l-arginine). There was no difference among groups in body weight, kidney weight, or glomerular generation number. Nephrogenic zone width was significantly reduced in the Ibuprofen group (123.5 ± 7.4 μm) compared with the 125d gestational control (176.1 ± 6.9 μm) and Untreated animals (169.7 ± 78.8 μm). In the Ibu+NOSi group, nephrogenic zone width averaged 152.7 ± 3.9 μm, which was not significantly different from any other group. Morphologically abnormal glomeruli were present at a range of 0.0-22.9% in the Untreated group, 0.0-6.1% in the Ibuprofen group, and 0.0-1.4% in the Ibu+NOSi group. In conclusion, early postnatal ibuprofen exposure is associated with a reduced nephrogenic zone width, which may suggest the early cessation of nephrogenesis following treatment. Ultimately, this may impact the number of nephrons formed in the preterm kidney.
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