ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2012
Spontaneous olfactory receptor neuron activity determines follower cell response properties.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 41 citations in OpenAlex.
- The innexin 7 gap junction protein contributes to synchronized activity in theFrontiers in neural circuits · 2025Article
- Response Plasticity ofInternational journal of molecular sciences · 2024Article
- Olfactory system structure and function in newly hatched and adult locusts.Scientific reports · 2024Article
- The frontal sharp transient in newborns: An endogenous neurobiomarker concomitant to the physiological and critical transitional period around delivery?Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Innate attraction and aversion to odors in locusts.PloS one · 2023Article
- Predictive olfactory learning in Drosophila.Scientific reports · 2021Article
- Structural and Functional Synaptic Plasticity Induced by Convergent Synapse Loss in theThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Flies Avoid Current Atmospheric COFrontiers in physiology · 2021Article
- Glomerulus-Selective Regulation of a Critical Period for Interneuron Plasticity in theThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Article
- Evolutionarily conserved anatomical and physiological properties of olfactory pathway through fourth-order neurons in a species of grasshopper (Hieroglyphus banian).Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2019Article
- Optimal compressed sensing strategies for an array of nonlinear olfactory receptor neurons with and without spontaneous activity.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Dynamic contrast enhancement and flexible odor codes.Nature communications · 2018Article
- The olfactory bulb as the entry site for prion-like propagation in neurodegenerative diseases.Neurobiology of disease · 2018Article
- Odor-evoked inhibition of olfactory sensory neurons drives olfactory perception in Drosophila.Nature communications · 2017Article
- Linking dynamics of the inhibitory network to the input structure.Journal of computational neuroscience · 2016Article
- Central processing in the mushroom bodies.Current opinion in insect science · 2014Article
- Heterogeneity and convergence of olfactory first-order neurons account for the high speed and sensitivity of second-order neurons.PLoS computational biology · 2014Article
- Temperature effects on the tympanal membrane and auditory receptor neurons in the locust.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2014Article
- Spontaneous and sensory-evoked activity in mouse olfactory sensory neurons with defined odorant receptors.Journal of neurophysiology · 2013Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Noisy or spontaneous activity is common in neural systems and poses a challenge to detecting and discriminating signals. Here we use the locust to answer fundamental questions about noise in the olfactory system: Where does spontaneous activity originate? How is this activity propagated or reduced throughout multiple stages of neural processing? What mechanisms favor the detection of signals despite the presence of spontaneous activity? We found that spontaneous activity long observed in the secondary projection neurons (PNs) originates almost entirely from the primary olfactory receptor neurons (ORNs) rather than from spontaneous circuit interactions in the antennal lobe, and that spontaneous activity in ORNs tonically depolarizes the resting membrane potentials of their target PNs and local neurons (LNs) and indirectly tonically depolarizes tertiary Kenyon cells (KCs). However, because these neurons have different response thresholds, in the absence of odor stimulation, ORNs and PNs display a high spontaneous firing rate but KCs are nearly silent. Finally, we used a simulation of the olfactory network to show that discrimination of signal and noise in the KCs is best when threshold levels are set so that baseline activity in PNs persists. Our results show how the olfactory system benefits from making a signal detection decision after a point of maximal information convergence, e.g., after KCs pool inputs from many PNs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.