ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2012
Effects of axonal topology on the somatic modulation of synaptic outputs.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 47 citations in OpenAlex.
- Bifurcation of neural firing patterns driven by potassium dynamics and neuron-electrode geometry during high-frequency stimulation.PLoS computational biology · 2026Article
- Dynamics of excitability in axonal trees.Biophysical journal · 2026Article
- Biophysical properties of the membrane influence spike initiation dynamics and neuronal excitability: a focus on Kv1 channels in myelinated axons.Proceedings. Biological sciences · 2025Review
- KThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Enhanced Release Probability without Changes in Synaptic Delay during Analogue-Digital Facilitation.Cells · 2024Article
- Beyond a Transmission Cable-New Technologies to Reveal the Richness in Axonal Electrophysiology.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Review
- Homeostatic regulation of axonal Kv1.1 channels accounts for both synaptic and intrinsic modifications in the hippocampal CA3 circuit.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Axonal NaScience advances · 2020Article
- Myelination Increases the Spatial Extent of Analog-Digital Modulation of Synaptic Transmission: A Modeling Study.Frontiers in cellular neuroscience · 2020Article
- Precise segmentation of densely interweaving neuron clusters using G-Cut.Nature communications · 2019Article
- Past and Future of Analog-Digital Modulation of Synaptic Transmission.Frontiers in cellular neuroscience · 2019Review
- Branching morphology determines signal propagation dynamics in neurons.Scientific reports · 2017Article
- Lamin A/C Is Required for ChAT-Dependent Neuroblastoma Differentiation.Molecular neurobiology · 2017Article
- The role of axonal Kv1 channels in CA3 pyramidal cell excitability.Scientific reports · 2017Article
- Na+ current in presynaptic terminals of the crayfish opener cannot initiate action potentials.Journal of neurophysiology · 2016Article
- Cortical Axons, Isolated in Channels, Display Activity-Dependent Signal Modulation as a Result of Targeted Stimulation.Frontiers in neuroscience · 2016Article
- Dynamic Control of Neurotransmitter Release by Presynaptic Potential.Frontiers in cellular neuroscience · 2016Review
- Presynaptic hyperpolarization induces a fast analogue modulation of spike-evoked transmission mediated by axonal sodium channels.Nature communications · 2015Article
- A software tool for the analysis of neuronal morphology data.International archives of medicine · 2014Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Depolarization of the neuronal soma augments synaptic output onto postsynaptic neurons via long-range, axonal cable properties. Here, we report that the range of this somatic influence is spatially restricted by not only axonal path length but also a branching-dependent decrease in axon diameter. Cell-attached recordings of action potentials (APs) from multiple axon branches of a rat hippocampal CA3 pyramidal cell revealed that an AP was broadened following a 20 mV depolarization of the soma and reverted to a normal width during propagation down the axon. The narrowing of the AP depended on the distance traveled by the AP and on the number of axon branch points through which the AP passed. These findings were confirmed by optical imaging of AP-induced calcium elevations in presynaptic boutons, suggesting that the somatic membrane potential modifies synaptic outputs near the soma but not long-projection outputs. Consistent with this prediction, whole-cell recordings from synaptically connected neurons revealed that depolarization of presynaptic CA3 pyramidal cells facilitated synaptic transmission to nearby CA3 pyramidal cells, but not to distant pyramidal cells in CA3 or CA1. Therefore, axonal geometry enables the differential modulation of synaptic output depending on target location.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.