ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2012
An essential role for modulation of hyperpolarization-activated current in the development of binaural temporal precision.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
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43 citing papers in PubMed, 70 citations in OpenAlex.
- A comprehensive review of HCN channel expression and IJournal of neurophysiology · 2025Review
- Cellular and synaptic specializations for sub-millisecond precision in the mammalian auditory brainstem.Frontiers in cellular neuroscience · 2025Review
- Review
- Anatomy of superior olivary complex and lateral lemniscus in Etruscan shrew.Scientific reports · 2024Article
- Principal neuron diversity in the murine lateral superior olive supports multiple sound localization strategies and segregation of information in higher processing centers.Communications biology · 2023Article
- Muscarinic Acetylcholine Receptors Modulate HCN Channel Properties in Vestibular Ganglion Neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Kv1 channels regulate variations in spike patterning and temporal reliability in the avian cochlear nucleus angularis.Journal of neurophysiology · 2022Article
- IProgress in biophysics and molecular biology · 2021Review
- Ion-channel degeneracy: Multiple ion channels heterogeneously regulate intrinsic physiology of rat hippocampal granule cells.Physiological reports · 2021Article
- Ambient noise exposure induces long-term adaptations in adult brainstem neurons.Scientific reports · 2021Article
- HCN channels in the mammalian cochlea: Expression pattern, subcellular location, and age-dependent changes.Journal of neuroscience research · 2021Article
- Activity-Dependent Calcium Signaling in Neurons of the Medial Superior Olive during Late Postnatal Development.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Minimal Number of Required Inputs for Temporally Precise Action Potential Generation in Auditory Brainstem Nuclei.Frontiers in cellular neuroscience · 2020Article
- Altered cochlear innervation in developing and mature naked and Damaraland mole rats.The Journal of comparative neurology · 2019Article
- Strengthening of the Efferent Olivocochlear System Leads to Synaptic Dysfunction and Tonotopy Disruption of a Central Auditory Nucleus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Enhanced Activation of HCN Channels Reduces Excitability and Spike-Timing Regularity in Maturing Vestibular Afferent Neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Distinct Distribution Patterns of Potassium Channel Sub-Units in Somato-Dendritic Compartments of Neurons of the Medial Superior Olive.Frontiers in cellular neuroscience · 2019Article
- A low-threshold potassium current enhances sparseness and reliability in a model of avian auditory cortex.PLoS computational biology · 2019Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
In sensory circuits of the brain, developmental changes in the expression and modulation of voltage-gated ion channels are a common occurrence, but such changes are often difficult to assign to clear functional roles. We have explored this issue in the binaural neurons of the medial superior olive (MSO), whose temporal precision in detecting the coincidence of binaural inputs dictates the resolution of azimuthal sound localization. We show that in MSO principal neurons of gerbils during the first week of hearing, a hyperpolarization-activated current (I(h)) progressively undergoes a 13-fold increase in maximal conductance, a >10-fold acceleration of kinetics, and, most surprisingly, a 30 mV depolarizing shift in the voltage dependence of activation. This period is associated with an upregulation of the hyperpolarization-activated and cyclic nucleotide-gated (HCN) channel subunits HCN1, HCN2, and HCN4 in the MSO, but only HCN1 and HCN4 were expressed strongly in principal neurons. I(h) recorded in nucleated patches from electrophysiologically mature MSO neurons (>P18) exhibited kinetics and an activation range nearly identical to the I(h) found in whole-cell recordings before hearing onset. These results indicate that the developmental changes in I(h) in MSO neurons can be explained predominantly by modulation from diffusible intracellular factors, and not changes in channel subunit composition. The exceptionally large modulatory changes in I(h), together with refinements in synaptic properties transform the coding strategy from one of summation and integration to the submillisecond coincidence detection known to be required for transmission of sound localization cues.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.