Trial reportThe Journal of neuroscience : the official journal of the Society for Neuroscience2012
Improved sequence learning with subthalamic nucleus deep brain stimulation: evidence for treatment-specific network modulation.
Trial report in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it, 64 citations in OpenAlex.
- Effect of Theta Burst Stimulation-Patterned rTMS on Motor and Nonmotor Dysfunction of Parkinson's Disease: A Systematic Review and Metaanalysis.Frontiers in neurology · 2021Pooled it
- Theta burst stimulation over the supplementary motor area in Parkinson's disease.Journal of neurology · 2015Trial
- Network modulation following sham surgery in Parkinson's disease.The Journal of clinical investigation · 2014Trial
- Preoperative network activity predicts the response to subthalamic DBS for Parkinson's disease.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2025Article
- A neurocomputational view of the effects of Parkinson's disease on speech production.Frontiers in human neuroscience · 2024Article
- Noninvasive theta-burst stimulation of the human striatum enhances striatal activity and motor skill learning.Nature neuroscience · 2023Article
- Functional Brain Networks to Evaluate Treatment Responses in Parkinson's Disease.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2023Article
- Prospective controlled study on the effects of deep brain stimulation on driving in Parkinson's disease.NPJ Parkinson's disease · 2023Article
- Functional brain networks in the evaluation of patients with neurodegenerative disorders.Nature reviews. Neurology · 2023Review
- Motor learning is independent of effects of subthalamic deep brain stimulation on motor execution.Brain communications · 2023Article
- Commentary on: A Network Approach to Understanding the Effects of Focused Ultrasound for Essential Tremor: Insights into Pathophysiology, Treatment, and Imaging Biomarkers.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2022Article
- Novel Non-invasive Transcranial Electrical Stimulation for Parkinson's Disease.Frontiers in aging neuroscience · 2022Review
- Neurotransmitters, Cell Types, and Circuit Mechanisms of Motor Skill Learning and Clinical Applications.Frontiers in neurology · 2021Review
- Deep Brain Stimulation of the Forel's Field for Dystonia: Preliminary Results.Frontiers in human neuroscience · 2021Article
- Stimulation of the Subthalamic Nucleus Changes Cortical-Subcortical Blood Flow Patterns During Speech: A Positron Emission Tomography Study.Frontiers in neurology · 2021Article
- Disruption of network for visual perception of natural motion in primary dystonia.Human brain mapping · 2018Article
- Reduced striatal dopamine release during motor skill acquisition in Parkinson's disease.PloS one · 2018Article
- Article
- Deep Brain Stimulation for Movement Disorders of Basal Ganglia Origin: Restoring Function or Functionality?Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2016Review
- Inverse Relationship between Basal Pacemaker Neuron Activity and Aversive Long-Term Memory Formation inFrontiers in cellular neuroscience · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 4 institutions in 1 country.
Funding
Abstract
We used a network approach to study the effects of anti-parkinsonian treatment on motor sequence learning in humans. Eight Parkinson's disease (PD) patients with bilateral subthalamic nucleus (STN) deep brain stimulation underwent H(2)(15)O positron emission tomography (PET) imaging to measure regional cerebral blood flow (rCBF) while they performed kinematically matched sequence learning and movement tasks at baseline and during stimulation. Network analysis revealed a significant learning-related spatial covariance pattern characterized by consistent increases in subject expression during stimulation (p = 0.008, permutation test). The network was associated with increased activity in the lateral cerebellum, dorsal premotor cortex, and parahippocampal gyrus, with covarying reductions in the supplementary motor area (SMA) and orbitofrontal cortex. Stimulation-mediated increases in network activity correlated with concurrent improvement in learning performance (p < 0.02). To determine whether similar changes occurred during dopaminergic pharmacotherapy, we studied the subjects during an intravenous levodopa infusion titrated to achieve a motor response equivalent to stimulation. Despite consistent improvement in motor ratings during infusion, levodopa did not alter learning performance or network activity. Analysis of learning-related rCBF in network regions revealed improvement in baseline abnormalities with STN stimulation but not levodopa. These effects were most pronounced in the SMA. In this region, a consistent rCBF response to stimulation was observed across subjects and trials (p = 0.01), although the levodopa response was not significant. These findings link the cognitive treatment response in PD to changes in the activity of a specific cerebello-premotor cortical network. Selective modulation of overactive SMA-STN projection pathways may underlie the improvement in learning found with stimulation.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.