Trial reportThe Journal of neuroscience : the official journal of the Society for Neuroscience2012
Neurochemical enhancement of conscious error awareness.
Trial report in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Success versus failure in cognitive control: Meta-analytic evidence from neuroimaging studies on error processing.Neuroscience and biobehavioral reviews · 2024Pooled it
- Spatial and temporal characteristics of error-related activity in the human brain.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Pooled it
- Efficacy of stimulants for cognitive enhancement in non-attention deficit hyperactivity disorder youth: a systematic review.Addiction (Abingdon, England) · 2014Pooled it
- Improving response inhibition in Parkinson's disease with atomoxetine.Biological psychiatry · 2015Trial
- Acute neuropharmacological effects of atomoxetine on inhibitory control in ADHD children: a fNIRS study.NeuroImage. Clinical · 2014Trial
- Cognitive-affective neural plasticity following active-controlled mindfulness intervention.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Trial
- Beyond attention: methylphenidate reduces dishonesty in healthy adults.Psychopharmacology · 2026Article
- The relationship between self-monitoring and cognitive strategy use in midlife and older adults.Journal of clinical and experimental neuropsychology · 2024Article
- Behavioral and neurophysiological signatures of cognitive control in humans and rats.The international journal of neuropsychopharmacology · 2024Article
- Neural and Behavioral Measures of Stress-induced Impairment in Error Awareness and Post-error Adjustment.Neuroscience bulletin · 2024Article
- Examining the neural correlates of error awareness in a large fMRI study.Cerebral cortex (New York, N.Y. : 1991) · 2022Article
- HIV infection is linked with reduced error-related default mode network suppression and poorer medication management abilities.Progress in neuro-psychopharmacology & biological psychiatry · 2021Article
- A salience misattribution model for addictive-like behaviors.Neuroscience and biobehavioral reviews · 2021Review
- Neural and behavioral traces of error awareness.Cognitive, affective & behavioral neuroscience · 2021Article
- Dopaminergic drug treatment remediates exaggerated cingulate prediction error responses in obsessive-compulsive disorder.Psychopharmacology · 2019Article
- Domain-general enhancements of metacognitive ability through adaptive training.Journal of experimental psychology. General · 2019Article
- Levodopa improves response inhibition and enhances striatal activation in early-stage Parkinson's disease.Neurobiology of aging · 2018Article
- Relationship of Alexithymia Ratings to Dopamine D2-type Receptors in Anterior Cingulate and Insula of Healthy Control Subjects but Not Methamphetamine-Dependent Individuals.The international journal of neuropsychopharmacology · 2016Article
- Monoaminergic Control of Cellular Glucose Utilization by Glycogenolysis in Neocortex and Hippocampus.Neurochemical research · 2015Review
- ADHD & Pharmacotherapy: Past, Present and Future: A Review of the Changing Landscape of Drug Therapy for Attention Deficit Hyperactivity Disorder.Therapeutic innovation & regulatory science · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
How the brain monitors ongoing behavior for performance errors is a central question of cognitive neuroscience. Diminished awareness of performance errors limits the extent to which humans engage in corrective behavior and has been linked to loss of insight in a number of psychiatric syndromes (e.g., attention deficit hyperactivity disorder, drug addiction). These conditions share alterations in monoamine signaling that may influence the neural mechanisms underlying error processing, but our understanding of the neurochemical drivers of these processes is limited. We conducted a randomized, double-blind, placebo-controlled, cross-over design of the influence of methylphenidate, atomoxetine, and citalopram on error awareness in 27 healthy participants. The error awareness task, a go/no-go response inhibition paradigm, was administered to assess the influence of monoaminergic agents on performance errors during fMRI data acquisition. A single dose of methylphenidate, but not atomoxetine or citalopram, significantly improved the ability of healthy volunteers to consciously detect performance errors. Furthermore, this behavioral effect was associated with a strengthening of activation differences in the dorsal anterior cingulate cortex and inferior parietal lobe during the methylphenidate condition for errors made with versus without awareness. Our results have implications for the understanding of the neurochemical underpinnings of performance monitoring and for the pharmacological treatment of a range of disparate clinical conditions that are marked by poor awareness of errors.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.