ArticleJournal of neurophysiology2012
Adenosine inhibits glutamatergic input to basal forebrain cholinergic neurons.
Article in Journal of neurophysiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 26 citations in OpenAlex.
- Activation of Basal Forebrain Astrocytes Induces Wakefulness without Compensatory Changes in Sleep Drive.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- The Neurobiological Basis of Sleep and Sleep Disorders.Physiology (Bethesda, Md.) · 2018Review
- Activation of basal forebrain purinergic P2 receptors promotes wakefulness in mice.Scientific reports · 2018Article
- Molecular Evidence of Adenosine Deaminase Linking Adenosine AFrontiers in pharmacology · 2018Article
- AMolecular neurobiology · 2017Review
- Intrinsic membrane properties and cholinergic modulation of mouse basal forebrain glutamatergic neurons in vitro.Neuroscience · 2017Article
- The menagerie of the basal forebrain: how many (neural) species are there, what do they look like, how do they behave and who talks to whom?Current opinion in neurobiology · 2017Review
- The role of adenosine in the maturation of sleep homeostasis in rats.Journal of neurophysiology · 2017Article
- Serum and Brain Metabolomic Variations Reveal Perturbation of Sleep Deprivation on Rats and Ameliorate Effect of Total Ginsenoside Treatment.International journal of genomics · 2017Article
- Dynorphin inhibits basal forebrain cholinergic neurons by pre- and postsynaptic mechanisms.The Journal of physiology · 2016Article
- Sleep-Wake Regulation and Its Impact on Working Memory Performance: The Role of Adenosine.Biology · 2016Review
- Disrupted sleep-wake regulation in type 1 equilibrative nucleoside transporter knockout mice.Neuroscience · 2015Article
- Cholinergic neurons of the basal forebrain mediate biochemical and electrophysiological mechanisms underlying sleep homeostasis.The European journal of neuroscience · 2015Article
- Presynaptic adenosine A₁ receptors modulate excitatory transmission in the rat basolateral amygdala.Neuropharmacology · 2014Article
- Purines released from astrocytes inhibit excitatory synaptic transmission in the ventral horn of the spinal cord.Frontiers in neural circuits · 2014Article
- Sites of action of sleep and wake drugs: insights from model organisms.Current opinion in neurobiology · 2013Review
- Adenosine inhibits the excitatory synaptic inputs to Basal forebrain cholinergic, GABAergic, and parvalbumin neurons in mice.Frontiers in neurology · 2013Article
- Pregnancy affects FOS rhythms in brain regions regulating sleep/wake state and body temperature in rats.Brain research · 2012Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Adenosine has been proposed as an endogenous homeostatic sleep factor that accumulates during waking and inhibits wake-active neurons to promote sleep. It has been specifically hypothesized that adenosine decreases wakefulness and promotes sleep recovery by directly inhibiting wake-active neurons of the basal forebrain (BF), particularly BF cholinergic neurons. We previously showed that adenosine directly inhibits BF cholinergic neurons. Here, we investigated 1) how adenosine modulates glutamatergic input to BF cholinergic neurons and 2) how adenosine uptake and adenosine metabolism are involved in regulating extracellular levels of adenosine. Our experiments were conducted using whole cell patch-clamp recordings in mouse brain slices. We found that in BF cholinergic neurons, adenosine reduced the amplitude of AMPA-mediated evoked glutamatergic excitatory postsynaptic currents (EPSCs) and decreased the frequency of spontaneous and miniature EPSCs through presynaptic A(1) receptors. Thus we have demonstrated that in addition to directly inhibiting BF cholinergic neurons, adenosine depresses excitatory inputs to these neurons. It is therefore possible that both direct and indirect inhibition may synergistically contribute to the sleep-promoting effects of adenosine in the BF. We also found that blocking the influx of adenosine through the equilibrative nucleoside transporters or inhibiting adenosine kinase and adenosine deaminase increased endogenous adenosine inhibitory tone, suggesting a possible mechanism through which adenosine extracellular levels in the basal forebrain are regulated.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.