ArticleCarcinogenesis2012
Evaluation of 19 susceptibility loci of breast cancer in women of African ancestry.
Article in Carcinogenesis, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers, 10 of them syntheses that pooled it.
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Who cites it
57 citing papers in PubMed, 10 syntheses or guidelines pooled it, 70 citations in OpenAlex.
- The 6q25.1 rs2046210 polymorphism is associated with an elevated susceptibility to breast cancer: A meta-analysis of 261,703 subjects.Molecular genetics & genomic medicine · 2019Pooled it
- Genome-wide association studies in women of African ancestry identified 3q26.21 as a novel susceptibility locus for oestrogen receptor negative breast cancer.Human molecular genetics · 2016Pooled it
- Association of three SNPs in TOX3 and breast cancer risk: Evidence from 97275 cases and 128686 controls.Scientific reports · 2015Pooled it
- Quantitative assessment of common genetic variants on chromosome 5p12 and hormone receptor status with breast cancer risk.PloS one · 2013Pooled it
- Association between 5p12 genomic markers and breast cancer susceptibility: evidence from 19 case-control studies.PloS one · 2013Pooled it
- Association between 1p11-rs11249433 polymorphism and breast cancer susceptibility: evidence from 15 case-control studies.PloS one · 2013Pooled it
- Pooled it
- Pooled it
- Quantitative assessment of 2q35-rs13387042 polymorphism and hormone receptor status with breast cancer risk.PloS one · 2013Pooled it
- Quantitative assessment of the association between rs2046210 at 6q25.1 and breast cancer risk.PloS one · 2013Pooled it
- Harnessing data science to control non-communicable diseases in Africa: a systematic review and gap analysis.Communications medicine · 2026Article
- Genome-wide association study identifies common variants associated with breast cancer in South African Black women.Nature communications · 2025Article
- Genome-wide association analyses of breast cancer in women of African ancestry identify new susceptibility loci and improve risk prediction.Nature genetics · 2024Article
- Article
- Associations between age of menarche and genetic variation in women of African descent: genome-wide association study and polygenic score analysis.Journal of epidemiology and community health · 2022Article
- The African Female Breast Cancer Epidemiology Study Protocol.Frontiers in oncology · 2022Article
- The Cancer Prevention Project of Philadelphia: preliminary findings examining diversity among the African diaspora.Ethnicity & health · 2021Article
- Impact of post-diagnosis weight change on survival outcomes in Black and White breast cancer patients.Breast cancer research : BCR · 2021Article
- Critical Analysis of Genome-Wide Association Studies: Triple Negative Breast CancerInternational journal of molecular sciences · 2020Review
- Germline variants and somatic mutation signatures of breast cancer across populations of African and European ancestry in the US and Nigeria.International journal of cancer · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
18 authors at 9 institutions in 3 countries.
Funding
Abstract
Multiple breast cancer susceptibility loci have been identified in genome-wide association studies (GWAS) in populations of European and Asian ancestry using array chips optimized for populations of European ancestry. It is important to examine whether these loci are associated with breast cancer risk in women of African ancestry. We evaluated 25 single nucleotide polymorphisms (SNPs) at 19 loci in a pooled case-control study of breast cancer, which included 1509 cases and 1383 controls. Cases and controls were enrolled in Nigeria, Barbados and the USA; all women were of African ancestry. We found significant associations for three SNPs, which were in the same direction and of similar magnitude as those reported in previous fine-mapping studies in women of African ancestry. The allelic odds ratios were 1.24 [95% confidence interval (CI): 1.04-1.47; P = 0.018] for the rs2981578-G allele (10q26/FGFR2), 1.34 (95% CI: 1.10-1.63; P = 0.0035) for the rs9397435-G allele (6q25) and 1.12 (95% CI: 1.00-1.25; P = 0.04) for the rs3104793-C allele (16q12). Although a significant association was observed for an additional index SNP (rs3817198), it was in the opposite direction to prior GWAS studies. In conclusion, this study highlights the complexity of applying current GWAS findings across racial/ethnic groups, as none of GWAS-identified index SNPs could be replicated in women of African ancestry. Further fine-mapping studies in women of African ancestry will be needed to reveal additional and causal variants for breast cancer.
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Registered trials
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