ArticleMolecular biology of the cell2012
Mex3c regulates insulin-like growth factor 1 (IGF1) expression and promotes postnatal growth.
Article in Molecular biology of the cell, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 35 citations in OpenAlex.
- RNA-Binding Proteins in Adipose Biology: From Mechanistic Understanding to Therapeutic Opportunities.International journal of molecular sciences · 2026Review
- Identification of the MEX3 family as potential biomarkers of hepatocellular carcinoma based on bioinformatics and experiments.Translational cancer research · 2025Article
- MEX3C induces cognitive impairment in mice through autophagy inhibition.Brain and behavior · 2023Article
- Post-transcriptional control of a stemness signature by RNA-binding protein MEX3A regulates murine adult neurogenesis.Nature communications · 2023Article
- Lentiviral vector mediated gene therapy for type I Dent disease ameliorates Dent disease-like phenotypes for three months in ClC-5 null mice.Molecular therapy. Methods & clinical development · 2022Article
- Differentially methylated CpGs in response to growth hormone administration in children with idiopathic short stature.Clinical epigenetics · 2022Article
- Oncogenic Potential of the Dual-Function Protein MEX3A.Biology · 2021Review
- JAK2-IGF1 axis in osteoclasts regulates postnatal growth in mice.JCI insight · 2021Article
- Mex3c mutation affects lactation through impairing milk ejection in female mice.Bioscience reports · 2020Article
- Construction of a Mex3c Gene-Deficient Mouse Model to Study C-FOS Expression in Hypothalamic Nuclei and Observe Morphological Differences in Embryonic Neural Tube Development.Medical science monitor : international medical journal of experimental and clinical research · 2020Article
- Whole genome analysis of water buffalo and global cattle breeds highlights convergent signatures of domestication.Nature communications · 2020Article
- The Role of the RNA-Binding Protein Family MEX-3 in Tumorigenesis.International journal of molecular sciences · 2020Review
- MicroRNA Let-7d-3p Contributes to Cardiac Protection via Targeting HMGA2.International journal of molecular sciences · 2019Article
- MEX3C regulates lipid metabolism to promote bladder tumorigenesis through JNK pathway.OncoTargets and therapy · 2019Article
- Gene Co-expression Analysis Indicates Potential Pathways and Regulators of Beef Tenderness in Nellore Cattle.Frontiers in genetics · 2018Article
- The human RNA-binding protein and E3 ligase MEX-3C binds the MEX-3-recognition element (MRE) motif with high affinity.The Journal of biological chemistry · 2017Article
- Identification of hMex-3A and its effect on human bladder cancer cell proliferation.Oncotarget · 2017Article
- MEX3C interacts with adaptor-related protein complex 2 and involves in miR-451a exosomal sorting.PloS one · 2017Article
- Multi-breed and multi-trait co-association analysis of meat tenderness and other meat quality traits in three French beef cattle breeds.Genetics, selection, evolution : GSE · 2016Article
- Pivotal role of RNA-binding E3 ubiquitin ligase MEX3C in RIG-I-mediated antiviral innate immunity.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Insulin-like growth factor 1 (IGF1) mediates the growth-promoting activities of growth hormone. How Igf1 expression is regulated posttranscriptionally is unclear. Caenorhabditis elegans muscle excess 3 (MEX-3) is involved in cell fate specification during early embryonic development through regulating mRNAs involved in specifying cell fate. The function of its mammalian homologue, MEX3C, is unknown. Here we show that MEX3C deficiency in Mex3c homozygous mutant mice causes postnatal growth retardation and background-dependent perinatal lethality. Hypertrophy of chondrocytes in growth plates is significantly impaired. Circulating and bone local production of IGF1 are both decreased in mutant mice. Mex3c mRNA is strongly expressed in the testis and the brain, and highly expressed in resting and proliferating chondrocytes of the growth plates. MEX3C is able to enrich multiple mRNA species from tissue lysates, including Igf1. Igf1 expression in bone is decreased at the protein level but not at the mRNA level, indicating translational/posttranslational regulation. We propose that MEX3C protein plays an important role in enhancing the translation of Igf1 mRNA, which explains the perinatal lethality and growth retardation observed in MEX3C-deficient mice.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.