ReviewReproductive biology and endocrinology : RB&E2012
Sex determination strategies in 2012: towards a common regulatory model?
Review in Reproductive biology and endocrinology : RB&E, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 48 citations in OpenAlex.
- Genotype-by-environment interactive effects and conflict solving during gonadal sex differentiation of pejerrey Odontesthes bonariensis, a fish with dual genotypic/environmental sex determination.Biology of sex differences · 2025Article
- Identification and characterization of the Dmrt1B gene in the oriental river prawn, Macrobrachium nipponense.Development genes and evolution · 2024Article
- Temperature-Induced Sex Differentiation in River Prawn (International journal of molecular sciences · 2024Article
- AOP Report: Adverse Outcome Pathways for Aromatase Inhibition or Androgen Receptor Agonism Leading to Male-Biased Sex Ratio and Population Decline in Fish.Environmental toxicology and chemistry · 2023Article
- Feminization of channel catfish with 17β-oestradiol involves methylation and expression of a specific set of genes independent of the sex determination region.Epigenetics · 2022Article
- DNA Methylation Difference between Female and Male Ussuri Catfish (Life (Basel, Switzerland) · 2022Article
- The Gene Toolkit Implicated in Functional Sex in Sparidae Hermaphrodites: Inferences From Comparative Transcriptomics.Frontiers in genetics · 2018Article
- Molecular identification and expression of the Foxl2 gene during gonadal sex differentiation in northern snakehead Channa argus.Fish physiology and biochemistry · 2015Article
- Sex-specific and developmental expression of Dmrt genes in the starlet sea anemone, Nematostella vectensis.EvoDevo · 2015Article
- Cloning and transcriptional expression of a novel gene during sex inversion of the rice field eel (Monopterus albus).SpringerPlus · 2015Article
- Genetics and timing of sex determination in the East African cichlid fish Astatotilapia burtoni.BMC genetics · 2014Article
- Epigenetic modification and inheritance in sexual reversal of fish.Genome research · 2014Article
- Review
- High temperature increases the masculinization rate of the all-female (XX) rainbow trout "Mal" population.PloS one · 2014Article
- Expression and sequence evolution of aromatase cyp19a1 and other sexual development genes in East African cichlid fishes.Molecular biology and evolution · 2013Article
- Lessons for inductive germline determination.Molecular reproduction and development · 2013Review
- Article
- R-spondins are involved in the ovarian differentiation in a teleost, medaka (Oryzias latipes).BMC developmental biology · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sex determination is a complicated process involving large-scale modifications in gene expression affecting virtually every tissue in the body. Although the evolutionary origin of sex remains controversial, there is little doubt that it has developed as a process of optimizing metabolic control, as well as developmental and reproductive functions within a given setting of limited resources and environmental pressure. Evidence from various model organisms supports the view that sex determination may occur as a result of direct environmental induction or genetic regulation. The first process has been well documented in reptiles and fish, while the second is the classic case for avian species and mammals. Both of the latter have developed a variety of sex-specific/sex-related genes, which ultimately form a complete chromosome pair (sex chromosomes/gonosomes). Interestingly, combinations of environmental and genetic mechanisms have been described among different classes of animals, thus rendering the possibility of a unidirectional continuous evolutionary process from the one type of mechanism to the other unlikely. On the other hand, common elements appear throughout the animal kingdom, with regard to a) conserved key genes and b) a central role of sex steroid control as a prerequisite for ultimately normal sex differentiation. Studies in invertebrates also indicate a role of epigenetic chromatin modification, particularly with regard to alternative splicing options. This review summarizes current evidence from research in this hot field and signifies the need for further study of both normal hormonal regulators of sexual phenotype and patterns of environmental disruption.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.