SynthesisProceedings. Biological sciences2012
How host heterogeneity governs tuberculosis reinfection?
Synthesis in Proceedings. Biological sciences, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed, 57 citations in OpenAlex.
- From Trait-Structured Within-Host Dynamics to SIR Models: A Multiscale Framework With Re-Exposure.Bulletin of mathematical biology · 2026Article
- Synthesizing selection mosaic theory and host-pathogen theory to explain large-scale pathogen coexistence.Nature communications · 2025Article
- Vaccine failure mode determines population-level impact of vaccination campaigns during epidemics.Journal of the Royal Society, Interface · 2025Article
- Tuberculosis vaccines and therapeutic drug: challenges and future directions.Molecular biomedicine · 2025Review
- Prior exposure to pathogens augments host heterogeneity in susceptibility and has key epidemiological consequences.PLoS pathogens · 2024Article
- Prior exposure to pathogens augments host heterogeneity in susceptibility and has key epidemiological consequences.bioRxiv : the preprint server for biology · 2024Article
- The source of individual heterogeneity shapes infectious disease outbreaks.Proceedings. Biological sciences · 2022Article
- Evolutionary dynamics in an SI epidemic model with phenotype-structured susceptible compartment.Journal of mathematical biology · 2021Article
- The impact of active case finding on transmission dynamics of tuberculosis: A modelling study.PloS one · 2021Article
- Depletion-of-susceptibles bias in influenza vaccine waning studies: how to ensure robust results.Epidemiology and infection · 2019Article
- Heterogeneous susceptibility to rotavirus infection and gastroenteritis in two birth cohort studies: Parameter estimation and epidemiological implications.PLoS computational biology · 2019Article
- The Importance of Heterogeneity to the Epidemiology of Tuberculosis.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2019Article
- Introducing risk inequality metrics in tuberculosis policy development.Nature communications · 2019Article
- Article
- Modelling heterogeneity in host susceptibility to tuberculosis and its effect on public health interventions.PloS one · 2018Article
- Geographic variation in pneumococcal vaccine efficacy estimated from dynamic modeling of epidemiological data post-PCV7.Scientific reports · 2017Article
- The role of mobility and health disparities on the transmission dynamics of Tuberculosis.Theoretical biology & medical modelling · 2017Article
- Is IPT more effective in high-burden settings? Modelling the effect of tuberculosis incidence on IPT impact.The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease · 2017Article
- Clinical trials: The mathematics of falling vaccine efficacy with rising disease incidence.Vaccine · 2016Article
- End TB strategy: the need to reduce risk inequalities.BMC infectious diseases · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 4 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recurrent episodes of tuberculosis (TB) can be due to relapse of latent infection or exogenous reinfection, and discrimination is crucial for control planning. Molecular genotyping of Mycobacterium tuberculosis isolates offers concrete opportunities to measure the relative contribution of reinfection in recurrent disease. Here, a mathematical model of TB transmission is fitted to data from 14 molecular epidemiology studies, enabling the estimation of relevant epidemiological parameters. Meta-analysis reveals that rates of reinfection after successful treatment are higher than rates of new TB, raising an important question about the underlying mechanism. We formulate two alternative mechanisms within our model framework: (i) infection increases susceptibility to reinfection or (ii) infection affects individuals differentially, thereby recruiting high-risk individuals to the group at risk for reinfection. The second mechanism is better supported by the fittings to the data, suggesting that reinfection rates are inflated through a population phenomenon that occurs in the presence of heterogeneity in individual risk of infection. As a result, rates of reinfection are higher when measured at the population level even though they might be lower at the individual level. Finally, differential host recruitment is modulated by transmission intensity, being less pronounced when incidence is high.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.