ArticleJournal of biosciences2012
Differential expression of ZFX gene in gastric cancer.
Article in Journal of biosciences, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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Who cites it
22 citing papers in PubMed, 36 citations in OpenAlex.
- Inhibition of circZFX suppresses malignant phenotypes in cholangiocarcinoma via the miR-654-3p/HDGF and YAP1 signaling activation.Biology direct · 2026Article
- Cross-cohort multi-omics analysis identifies novel clusters driven by epithelial-mesenchymal transition signatures in gastric cancer.Cancer cell international · 2026Article
- Reduction of ZFX levels decreases histone H4 acetylation and increases Pol2 pausing at target promoters.Nucleic acids research · 2024Article
- Characterization of the ZFX family of transcription factors that bind downstream of the start site of CpG island promoters.Nucleic acids research · 2020Article
- Epidemiologic Study of Gastric Cancer in Iran: A Systematic Review.Clinical and experimental gastroenterology · 2020Review
- SE translocation gene but not zinc finger or X-linked factor is down-regulated in gastric cancer.Gastroenterology and hepatology from bed to bench · 2020Article
- Differential Expression Profile of ZFX Variants Discriminates Breast Cancer SubtypesIranian biomedical journal · 2019Article
- Gene Expression Analysis of Two Epithelial-mesenchymal Transition-related Genes: Long NoncodingAdvanced biomedical research · 2018Article
- miR-101 targeting ZFX suppresses tumor proliferation and metastasis by regulating the MAPK/Erk and Smad pathways in gallbladder carcinoma.Oncotarget · 2016Article
- Dysregulation of zinc finger protein, X-linked (ZFX) impairs cell proliferation and induces apoptosis in human oral squamous cell carcinorma.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2015Article
- Expression of ZFX gene correlated with the central features of the neoplastic phenotype in human brain tumors with distinct phenotypes.Advanced biomedical research · 2015Article
- High expression of Zinc-finger protein X-linked is associated with reduced E-cadherin expression and unfavorable prognosis in nasopharyngeal carcinoma.International journal of clinical and experimental pathology · 2015Article
- Zinc finger X-chromosomal protein (ZFX) is a significant prognostic indicator and promotes cellular malignant potential in gallbladder cancer.Cancer biology & therapy · 2015Article
- SIX1 overexpression in diffuse-type and grade III gastric tumors: Features that are associated with poor prognosis.Advanced biomedical research · 2015Article
- Zinc finger protein x-linked (ZFX) contributes to patient prognosis, cell proliferation and apoptosis in human laryngeal squamous cell carcinoma.International journal of clinical and experimental pathology · 2015Article
- Expression profile of ZFX isoform3/variant 5 in gastric cancer tissues and its association with tumor size.Iranian journal of basic medical sciences · 2014Article
- EYA1 expression in gastric carcinoma and its association with clinicopathological characteristics: a pilot study.Medical oncology (Northwood, London, England) · 2014Article
- Association of HOTAIR expression in gastric carcinoma with invasion and distant metastasis.Advanced biomedical research · 2014Article
- Article
- Indolent small intestinal CD4+ T-cell lymphoma is a distinct entity with unique biologic and clinical features.PloS one · 2013Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Gastric cancer accounts for 8% of the total cancer cases and 10% of total cancer deaths worldwide. In Iran, gastric cancer is the leading cause of national cancer-related mortality. Most human cancers show substantial heterogeneity. The cancer stem cell (CSC) hypothesis has been proposed to reconcile this heterogeneity. ZFX encodes a member of the krueppel C2H2-type zinc-finger protein family that is required as a transcriptional regulator for self-renewal of stem cells. A total of 30 paired tissue gastric samples were examined for ZFX gene expression by quantitative real-time RT-PCR. Although the relative expression of the gene was significantly high in 47% of the examined tumour tissues, its expression was low in the others (53%). There was a statistically significant association between the ZFX gene expression and different tumour types and grades. This is the first report that shows ZFX was differentially expressed in gastric cancer. Of note, it was overexpressed in diffused-type and grade III gastric tumoural tissues. Due to this, ZFX may have the potential to be used as a target for therapeutic interventions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.