ArticleThe journal of histochemistry and cytochemistry : official journal of the Histochemistry Society2012
Spatial and temporal localization of WNT signaling proteins in a mouse model of distraction osteogenesis.
Article in The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 26 citations in OpenAlex.
- Mechanical‑immune feedback regulation in distraction osteogenesis: From mechanotransduction to immune microenvironment remodeling (Review).Molecular medicine reports · 2026Review
- Mechanotransduction and musculoskeletal regeneration: Molecular mechanisms and interdisciplinary applications.Genes & diseases · 2026Review
- Activation of Wnt signaling in human fracture callus and nonunion tissues.Bone reports · 2024Article
- An Inexpensive 3D Printed Mouse Model of Successful, Complication-free Long Bone Distraction Osteogenesis.Plastic and reconstructive surgery. Global open · 2023Article
- Immunomodulatory effects and mechanisms of distraction osteogenesis.International journal of oral science · 2022Review
- Thy1 (CD90) expression is regulated by DNA methylation during adipogenesis.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2019Article
- 4-Molecules (Basel, Switzerland) · 2019Article
- Fak-Mapk, Hippo and Wnt signalling pathway expression and regulation in distraction osteogenesis.Cell proliferation · 2018Article
- Assessment of the effect of systemic delivery of sclerostin antibodies on Wnt signaling in distraction osteogenesis.Journal of bone and mineral metabolism · 2018Article
- Role of CtBP2 in the Apoptosis of Retinal Ganglion Cells.Cellular and molecular neurobiology · 2015Article
- Comprehensive Review of Adipose Stem Cells and Their Implication in Distraction Osteogenesis and Bone Regeneration.BioMed research international · 2015Review
- The effect of altering the mechanical loading environment on the expression of bone regenerating molecules in cases of distraction osteogenesis.Frontiers in endocrinology · 2014Review
- The effect of heparan sulfate application on bone formation during distraction osteogenesis.PloS one · 2013Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
While the surgical procedure of distraction osteogenesis (DO) is very successful in the treatment of orthopedic conditions, its major limitation of slow bone formation in the distracted gap has prompted numerous attempts to understand and accelerate this slow bone formation. Interestingly, WNT/FZD signaling has been identified as a critical pathway in mediating bone formation and regeneration but has not yet been studied in the context of DO. The objective of this study was to determine the spatial and temporal localization of endogenous WNT signaling proteins at various times of bone formation in a wild-type mouse model of DO. In this study, the DO protocol performed on mice consisted of three phases: latency (5 days), distraction (12 days), and consolidation (34 days). Our immunohistochemical findings of distracted bone specimens show an increased expression of WNT ligands (WNT4 and WNT10A), receptors (FZD1 and 2, LRP5 and 6), β-catenin, and pathway antagonizers (DKK1; CTBP1 and 2; sFRP1, 2, and 4) during the distraction phase, which were then down-regulated during consolidation. This is the first published report to show an activation of the WNT pathway in DO and could help identify WNT as a potential therapeutic target in accelerating bone regeneration during DO.
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