Evidence map›Paper›PMID 22356731›Full record

ArticleGenome biology2012

Extensive regulation of NAGNAG alternative splicing: new tricks for the spliceosome?

Anke Busch, Klemens J Hertel

Open access · bronzeAbstract read
In one paragraph

Article in Genome biology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.7field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 18 citations in OpenAlex.

  1. Control of 3' splice site selection inRNA (New York, N.Y.) · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Anke BuschDepartment of Microbiology and Molecular Genetics, School of Medicine, University of California, Irvine, Irvine, CA 92697-4025, USA.
Klemens J Hertel
University of California, Irvine · US

Funding

MECHANISMS OF ENHANCER DEPENDENT SPLICE SITE ACTIVATIONR01GM062287 · NIGMS · UNIVERSITY OF CALIFORNIA-IRVINE · PI HERTEL, KLEMENS J · 2001 to 2019
$4.8M
The role of alternative pre-mRNA splicing in breast cancer progressionR21CA149548 · NCI · UNIVERSITY OF CALIFORNIA-IRVINE · PI HERTEL, KLEMENS J · 2010 to 2011
$385k
NCI NIH HHS R21 CA149548NIGMS NIH HHS R01 GM062287NIGMS NIH HHS R01 GM62287
6 · The paper itself

Abstract

A recent study using massive parallel sequencing demonstrates unequivocally that alternative tandem acceptor splicing is tissue-specifically regulated.

Indexed as

Alternative SplicingExonsHigh-Throughput Nucleotide SequencingHumansIntronsOrgan SpecificityProtein IsoformsRNA Splice SitesSpliceosomesProtein IsoformsRNA Splice Sites

Identifiers

PMID22356731
PMCPMC3334559
OpenAlexW2044429827

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.