ReviewClinical drug investigation2012
Pain mechanisms in patients with chronic pain.
Review in Clinical drug investigation, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it, 140 citations in OpenAlex.
- Pooled it
- Brain-based measures of nociception during general anesthesia with remifentanil: A randomized controlled trial.PLoS medicine · 2022Trial
- Brain sensory network activity underlies reduced nociceptive initiated and nociplastic pain via acupuncture in fibromyalgia.Communications medicine · 2026Article
- Investigating the Influence of Experimentally Induced Secondary Hyperalgesia on Pain Prediction Error Encoding in Healthy Individuals: A Novel Virtual Reality Protocol.European journal of pain (London, England) · 2025Article
- Review
- Neurochemical crossroads: exploring the neurotransmitter network in chronic pain and depression comorbidity.Frontiers in molecular neuroscience · 2025Review
- Histone deacetylases: the critical enzymes for microglial activation involved in neuropathic pain.Frontiers in pharmacology · 2025Review
- Cultural Adaptation and Psychometric Validation of the Simplified Chinese Version of the Fear Avoidance Component Scale (FACS).Pain research & management · 2024Article
- Multimodal non-invasive non-pharmacological therapies for chronic pain: mechanisms and progress.BMC medicine · 2023Review
- Development, refinement, and validation of an equine musculoskeletal pain scale.Frontiers in pain research (Lausanne, Switzerland) · 2023Article
- The Beneficial Effects of Ultramicronized Palmitoylethanolamide in the Management of Neuropathic Pain and Associated Mood Disorders Induced by Paclitaxel in Mice.Biomolecules · 2022Article
- Effectiveness of pulsed radiofrequency on the medial cervical branches for cervical facet joint pain.World journal of clinical cases · 2022Article
- Application of Bioinformatics Methods to Identify Key Genes and Functions in Chronic Pelvic Pain.Evidence-based complementary and alternative medicine : eCAM · 2021Article
- Utilization of Intravenous Lidocaine Infusion for the Treatment of Refractory Chronic Pain.Anesthesiology and pain medicine · 2020Review
- Clinical applications of neurochemical and electrophysiological measurements for closed-loop neurostimulation.Neurosurgical focus · 2020Article
- Attenuation of the Diffuse Noxious Inhibitory Controls in Chronic Joint Inflammatory Pain Is Accompanied by Anxiodepressive-Like Behaviors and Impairment of the Descending Noradrenergic Modulation.International journal of molecular sciences · 2020Article
- Pharmacological rationale for tapentadol therapy: a review of new evidence.Journal of pain research · 2019Review
- Effects of paclitaxel on the development of neuropathy and affective behaviors in the mouse.Neuropharmacology · 2017Article
- A Novel Brucine Gel Transdermal Delivery System Designed for Anti-Inflammatory and Analgesic Activities.International journal of molecular sciences · 2017Article
- Virus Infections Incite Pain Hypersensitivity by Inducing Indoleamine 2,3 Dioxygenase.PLoS pathogens · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The mechanisms involved in the development of chronic pain are varied and complex. Pain processes are plastic and unrelieved pain may lead to changes in the neural structure involved in pain generation. Nociceptive pain announces the presence of a potentially damaging stimulus that occurs when noxious stimuli activate primary afferent neurons. Neuropathic pain is initiated or caused by a primary lesion or dysfunction in the nervous system resulting from trauma, infection, ischaemia, cancer or other causes such as chemotherapy. The exact mechanisms involved in the pathophysiology of chronic pain are not well understood, but rapid and long-term changes are thought to occur in parts of the central nervous system that are involved in the transmission and modulation of pain following injury. Peripheral and central sensitization of sensory nerve fibres are the primary reasons for hypersensitivity to pain after injury, and mainly occur in inflammatory and neuropathic pain. During these processes the sensation of pain is enhanced as a result of changes in the environment, the nerve fibres and modifications of the functional properties and the genetic programme of primary and secondary afferent neurons. Non-steroidal anti-inflammatory drugs and opioid analgesics are two of the most common classes of drugs used for the treatment of pain. Response to drug treatment shows significant interindividual variability and can lead to side effects. The neurobiological mechanisms that cause pain may account for the different types of pain observed. Identification of these mechanisms may allow us to move from an empirical therapeutic approach to one that it is specifically targeted at the particular mechanisms of the type of pain experienced by an individual patient.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.