ArticleClinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology2012
Low serum high-density lipoprotein cholesterol in childhood is associated with adolescent asthma.
Article in Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 65 citations in OpenAlex.
- Glycolytic-Cholesterol Subtypes of Severe Asthma Reveal Distinct Immune-Inflammatory and Metabolic Phenotypes.Journal of inflammation research · 2026Article
- The Role of Lipid Metabolism Disorders in Rhinitis and Asthma.Combinatorial chemistry & high throughput screening · 2026Review
- Machine learning and nomogram prediction model to explore the relationship between monocyte-to-high-density lipoprotein cholesterol ratio and asthma: results from the NHANES 2001-2018.European journal of medical research · 2025Article
- Mediating role of basophils in the triacylglycerol-asthma link: a Mendelian randomization study.3 Biotech · 2025Article
- Association Between Triglyceride-Glucose Index and Development of Asthma in US Adolescents: A Cross-Sectional Study.Allergy, asthma & immunology research · 2024Article
- Repurposing lipid-lowering drugs on asthma and lung function: evidence from a genetic association analysis.Journal of translational medicine · 2024Article
- Association between dyslipidemia and asthma in children: a systematic review and multicenter cohort study using a common data model.Clinical and experimental pediatrics · 2023Article
- HDL and sleep: beyond cardiovascular diseases and allergy.Sleep and biological rhythms · 2022Article
- Lipid Nutrition in Asthma.Cell biochemistry and biophysics · 2021Review
- High-Density Lipoprotein (HDL) in Allergy and Skin Diseases: Focus on Immunomodulating Functions.Biomedicines · 2020Review
- No Associations Between Serum Lipid Levels or HOMA-IR and Asthma in Children and Adolescents: A NHANES AnalysisJournal of clinical research in pediatric endocrinology · 2019Article
- Exposure to PMLipids in health and disease · 2019Article
- Semantic integration of clinical laboratory tests from electronic health records for deep phenotyping and biomarker discovery.NPJ digital medicine · 2019Article
- [Association of blood lipids with childhood asthma].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2018Article
- Association of Serum Lipids and Obstructive Lung Disease in Hispanic/Latino Adults of Diverse Backgrounds.Journal of pulmonary & respiratory medicine · 2017Article
- Cholesterol-sensing liver X receptors stimulate Th2-driven allergic eosinophilic asthma in mice.Immunity, inflammation and disease · 2016Article
- Interaction between allergic asthma and atherosclerosis.Translational research : the journal of laboratory and clinical medicine · 2016Review
- Shared genetic variants between serum levels of high-density lipoprotein cholesterol and wheezing in a cohort of children from Cyprus.Italian journal of pediatrics · 2016Article
- Serum apolipoprotein A-I and large high-density lipoprotein particles are positively correlated with FEV1 in atopic asthma.American journal of respiratory and critical care medicine · 2015Article
- Asthma and metabolic syndrome: Current knowledge and future perspectives.World journal of clinical cases · 2015Review
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Authors and funding
12 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundWhilst emerging evidence from animal and cell experiments has shown high-density lipoprotein cholesterol to have anti-inflammatory effects consistent with a protective role in asthma, human studies investigating the relationship of high-density lipoprotein cholesterol with asthma have produced conflicting results.
objectiveTo examine the association between serum lipids among Cypriot children aged 11-12 years and prevalence of asthma at age 15-17 years.
methodsIn 3982 children, we assessed serum lipids, body mass index and maximal oxygen consumption at baseline (2001-2003) and explored associations with respiratory health at follow-up (2007) using multiple logistic regression models.
resultsLower levels of high-density lipoprotein cholesterol at age 11-12 years were found in subjects who reported ever asthma (58.2 vs. 60.0 mg/dL, P = 0.005) and active asthma (57.5 vs. 59.9 mg/dL, P = 0.010) in adolescence, in comparison with their respective reference groups. Total cholesterol, low-density lipoprotein and triglycerides had no association with any of the asthma outcomes. In contrast, with estimated odds ratios of 1.89 (95% CI 1.19-3.00) and 1.89 (95% CI 1.02-3.53), ever asthma and active asthma respectively appeared particularly pronounced among those who at baseline had high-density lipoprotein cholesterol <40 mg/dL, even after adjusting for potential confounders including body mass index and maximal oxygen consumption. CONCLUSIONS & CLINICAL RELEVANCE: Low-serum high-density lipoprotein cholesterol in childhood is associated with an increased risk for asthma in adolescence, suggesting a potential role of this lipoprotein in the pathogenesis of paediatric asthma.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.