ReviewAntioxidants & redox signaling2012
Chemical methods for the direct detection and labeling of S-nitrosothiols.
Review in Antioxidants & redox signaling, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed.
- Effect of Normobaric Hypoxia on Alterations in Redox Homeostasis, Nitrosative Stress, Inflammation, and Lysosomal Function following Acute Physical Exercise.Oxidative medicine and cellular longevity · 2022Article
- Bioorthogonal Reactions of Triarylphosphines and Related Analogues.Chemical reviews · 2021Review
- A clickable probe for versatile characterization of S-nitrosothiols.Redox biology · 2020Article
- Specific Reactions of RSNO, HSNO, and HNO and Their Applications in the Design of Fluorescent Probes.Chemistry (Weinheim an der Bergstrasse, Germany) · 2020Review
- Automated Online Solid-Phase Derivatization for Sensitive Quantification of Endogenous S-Nitrosoglutathione and Rapid Capture of Other Low-Molecular-Mass S-Nitrosothiols.Analytical chemistry · 2018Article
- Computational Structural Biology ofFrontiers in oncology · 2018Review
- Biomarkers of oxidative and nitro-oxidative stress: conventional and novel approaches.British journal of pharmacology · 2017Review
- Quantitative proteomic characterization of redox-dependent post-translational modifications on protein cysteines.Molecular bioSystems · 2017Review
- Protein Posttranslational Modifications: Roles in Aging and Age-Related Disease.Oxidative medicine and cellular longevity · 2017Review
- Proteomic approaches to quantify cysteine reversible modifications in aging and neurodegenerative diseases.Proteomics. Clinical applications · 2016Review
- Identification of novel S-nitrosation sites in soluble guanylyl cyclase, the nitric oxide receptor.Journal of proteomics · 2016Article
- Comparison of Reductive Ligation-Based Detection Strategies for Nitroxyl (HNO) and S-Nitrosothiols.ChemistryOpen · 2016Article
- The preparation and characterization of nitric oxide releasing silicone rubber materials impregnated withJournal of materials chemistry. B · 2016Article
- The Expanding Landscape of the Thiol Redox Proteome.Molecular & cellular proteomics : MCP · 2016Review
- Chemical probes for molecular imaging and detection of hydrogen sulfide and reactive sulfur species in biological systems.Chemical Society reviews · 2015Review
- Measurement of NO in biological samples.British journal of pharmacology · 2015Review
- Effects of ionizing radiation on biological molecules--mechanisms of damage and emerging methods of detection.Antioxidants & redox signaling · 2014Review
- Monitoring in vivo reversible cysteine oxidation in proteins using ICAT and mass spectrometry.Nature protocols · 2014Article
- Direct methods for detection of protein S-nitrosylation.Methods (San Diego, Calif.) · 2013Review
- Mechanism-based triarylphosphine-ester probes for capture of endogenous RSNOs.Journal of the American Chemical Society · 2013Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
significancePosttranslational modification of proteins through phosphorylation, glycosylation, and oxidation adds complexity to the proteome by reversibly altering the structure and function of target proteins in a highly controlled fashion. RECENT ADVANCES: The study of reversible cysteine oxidation highlights a role for this oxidative modification in complex signal transduction pathways. Nitric oxide (NO), and its respective metabolites (including reactive nitrogen species), participates in a variety of these cellular redox processes, including the reversible oxidation of cysteine to S-nitrosothiols (RSNOs). RSNOs act as endogenous transporters of NO, but also possess beneficial effects independent of NO-related signaling, which suggests a complex and versatile biological role. In this review, we highlight the importance of RSNOs as a required posttranslational modification and summarize the current methods available for detecting S-nitrosation. CRITICAL ISSUES: Given the limitations of these indirect detection methods, the review covers recent developments toward the direct detection of RSNOs by phosphine-based chemical probes. The intrinsic properties that dictate this phosphine/RSNO reactivity are summarized. In general, RSNOs (both small molecule and protein) react with phosphines to yield reactive S-substituted aza-ylides that undergo further reactions leading to stable RSNO-based adducts. FUTURE DIRECTIONS: This newly explored chemical reactivity forms the basis of a number of exciting potential chemical methods for protein RSNO detection in biological systems.
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Registered trials
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