ArticleJournal of the American Chemical Society2012
Highly diastereoselective synthesis of tetrahydropyridines by a C-H activation-cyclization-reduction cascade.
Article in Journal of the American Chemical Society, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed.
- Alkyne Carboamination with Imines Catalyzed by [pyOrganometallics · 2025Article
- Modular synthesis of unsaturated aza-heterocycles via copper catalyzed multicomponent cascade reaction.iScience · 2023Article
- Phosphine Oxide-Promoted Rh(I)-Catalyzed C-H Cyclization of Benzimidazoles with Alkenes.Molecules (Basel, Switzerland) · 2023Article
- Bespoke library docking for 5-HTNature · 2022Article
- Article
- Cascade aza-Wittig/6π-Electrocyclization in the Synthesis of 1,6-Dihydropyridines.Organic letters · 2021Article
- A General Iridium-Catalyzed Reductive Dienamine Synthesis Allows a Five-Step Synthesis of Catharanthine via the Elusive Dehydrosecodine.Journal of the American Chemical Society · 2021Article
- Substituted Dihydropyridine Synthesis by Dearomatization of Pyridines.Angewandte Chemie (International ed. in English) · 2021Article
- Rhodium-Catalyzed C-H Alkenylation/Electrocyclization Cascade Provides Dihydropyridines That Serve as Versatile Intermediates to Diverse Nitrogen Heterocycles.Accounts of chemical research · 2021Review
- Highly Diastereoselective Functionalization of Piperidines by Photoredox-Catalyzed α-Amino C-H Arylation and Epimerization.Journal of the American Chemical Society · 2020Article
- Recent advances in the application of ring-closing metathesis for the synthesis of unsaturated nitrogen heterocycles.Synthesis · 2019Article
- π-Facial Selectivities in Hydride Reductions of Hindered Endocyclic Iminium Ions.The Journal of organic chemistry · 2019Article
- New Regio- and Stereoselective Cascades via Unstabilized Azomethine Ylide Cycloadditions for the Synthesis of Highly Substituted Tropane and Indolizidine Frameworks.Journal of the American Chemical Society · 2016Article
- Metal-Free C-H Alkyliminylation and Acylation of Alkenes with Secondary Amides.Scientific reports · 2016Article
- Merging rhodium-catalysed C-H activation and hydroamination in a highly selective [4+2] imine/alkyne annulation.Nature communications · 2016Article
- Synthesis of ent-ketorfanol via a C-H alkenylation/torquoselective 6π electrocyclization cascade.Angewandte Chemie (International ed. in English) · 2015Article
- RhChemical science · 2015Article
- Regio- and Diastereoselective Synthesis of Highly Substituted, Oxygenated Piperidines from Tetrahydropyridines.The Journal of organic chemistry · 2015Article
- Rh(I)-Catalyzed Cycloisomerization of 1,6-Enynes.Synlett : accounts and rapid communications in synthetic organic chemistry · 2015Article
- Convergent Synthesis of Diverse Tetrahydropyridines via Rh(I)-Catalyzed C-H Functionalization Sequences.Organic process research & development · 2014Review
Corrections and comments
- Erratum issued
Authors and funding
5 authors.
Funding
Abstract
A versatile reaction cascade leading to highly substituted 1,2,3,6-tetrahydropyridines has been developed. It comprises rhodium(I)-catalyzed C-H activation-alkyne coupling followed by electrocyclization and subsequent acid/borohydride-promoted reduction. This one-pot procedure affords the target compounds in up to 95% yield with >95% diastereomeric purity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.