ArticleScientific reports2012
Discrimination of the oral microbiota associated with high hydrogen sulfide and methyl mercaptan production.
Article in Scientific reports, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 2 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
44 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Daily use of chlorine dioxide effectively treats halitosis: A meta-analysis of randomised controlled trials.PloS one · 2023Pooled it
- Intraindividual variation in core microbiota in peri-implantitis and periodontitis.Scientific reports · 2014Pooled it
- Trial
- A randomised, double-blind clinical study into the effect of zinc citrate trihydrate toothpaste on oral plaque microbiome ecology and function.Scientific reports · 2025Trial
- [Research Progress on Microbiome-Driven Mechanisms and Intervention Strategies for Oral Malodor].Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2026Review
- Microbiota-based therapies in oral health and disorders.Folia microbiologica · 2025Review
- Oral Administration of Propolis and Lysozyme Combination Improves Feline Oral Health and Modulates Systemic Inflammatory and Oxidative Responses.Antioxidants (Basel, Switzerland) · 2025Article
- Dencichine attenuates the virulence of Fusobacterium nucleatum by targeting hydrogen sulfide-producing enzyme.International microbiology : the official journal of the Spanish Society for Microbiology · 2025Article
- Two marine sulfur-reducing bacteria co-culture is essential for productive infection by a T4-likeHeliyon · 2024Article
- Oral Microbiome: A Review of Its Impact on Oral and Systemic Health.Microorganisms · 2024Review
- Oral microbial profiles of extrinsic black tooth stain in primary dentition: A literature review.Journal of dental sciences · 2024Review
- Evaluation of the Oral Microbiome before and after Treatments for Halitosis with Photodynamic Therapy and Probiotics-Pilot Study.Healthcare (Basel, Switzerland) · 2024Article
- Dynamic changes in microbial communities and flavor during different fermentation stages of proso millet Baijiu, a new product from Shanxi light-flavored Baijiu.Frontiers in microbiology · 2024Article
- Distinctive patterns of sulfide- and butyrate-metabolizing bacteria after bariatric surgery: potential implications for colorectal cancer risk.Gut microbes · 2023Article
- Non-Surgical Periodontal Treatment Impact on Subgingival Microbiome and Intra-Oral Halitosis.International journal of molecular sciences · 2023Article
- Oral microbiome as a co-mediator of halitosis and periodontitis: a narrative review.Frontiers in oral health · 2023Review
- The tongue biofilm metatranscriptome identifies metabolic pathways associated with the presence or absence of halitosis.NPJ biofilms and microbiomes · 2022Article
- Oral microbiota populations of adult dogs consuming wet or dry foods.Journal of animal science · 2022Article
- Diurnal and eating-associated microbial patterns revealed via high-frequency saliva sampling.Genome research · 2022Article
- Effect of antimicrobial photodynamic therapy with red led and methylene blue on the reduction of halitosis: controlled microbiological clinical trial.Lasers in medical science · 2022Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Both hydrogen sulfide (H2S) and methyl mercaptan (CH(3)SH) are frequently detected in large amounts in malodorous mouth air. We investigated the bacterial composition of saliva of 30 subjects with severe oral malodor exhibiting extreme CH(3)SH/H(2)S ratios (high H(2)S but low CH(3)SH concentrations, n 5 14; high CH(3)SH but low H2S concentrations, n 5 16) and 13 subjects without malodor, using barcoded pyrosequencing analysis of the 16S rRNA gene. Phylogenetic community analysis with the UniFrac distance metric revealed a distinct bacterial community structure in each malodor group. The H2S group showed higher proportions of the genera Neisseria, Fusobacterium, Porphyromonas and SR1 than the other two groups, whereas the CH(3)SH group had higher proportions of the genera Prevotella, Veillonella,Atopobium, Megasphaera, and Selenomonas. Our results suggested that distinct bacterial populations in the oral microbiota are involved in production of high levels of H2S and CH3SH in the oral cavity.
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