ArticleScientific reports2012
Drosophila growth-blocking peptide-like factor mediates acute immune reactions during infectious and non-infectious stress.
Article in Scientific reports, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 64 citations in OpenAlex.
- Parallel adaptive responses to postponed reproduction increase lifespan and immune defense.bioRxiv : the preprint server for biology · 2026Article
- Recent insights in the development and functions of insect hemocytes.Current opinion in insect science · 2026Review
- The NFκB Dif is required for behavioral and molecular correlates of sleep homeostasis in Drosophila.Sleep · 2024Article
- Drosophila cytokine GBP2 exerts immune responses and regulates GBP1 expression through GPCR receptor Mthl10.Insect biochemistry and molecular biology · 2024Article
- The NFκBbioRxiv : the preprint server for biology · 2023Article
- Preferential binding of DAP-PGs by major peptidoglycan recognition proteins found in cell-free hemolymph of Manduca sexta.Insect biochemistry and molecular biology · 2022Article
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- MountingSTAR protocols · 2022Article
- Proteolytic activation of Growth-blocking peptides triggers calcium responses through the GPCR Mthl10 during epithelial wound detection.Developmental cell · 2021Article
- N-acetyl-l-tyrosine is an intrinsic triggering factor of mitohormesis in stressed animals.EMBO reports · 2020Article
- Comparative RNA-Seq analyses of Drosophila plasmatocytes reveal gene specific signatures in response to clean injury and septic injury.PloS one · 2020Article
- Functional Multiplicity of an Insect Cytokine Family Assists Defense Against Environmental Stress.Frontiers in physiology · 2019Review
- The Drosophila cytokine, GBP: A model that illuminates the yin-yang of inflammation and longevity in humans?Cytokine · 2018Article
- Cytokine signaling throughProceedings of the National Academy of Sciences of the United States of America · 2017Article
- Solution Structure and Expression Profile of an Insect Cytokine: Manduca sexta Stress Response Peptide-2.Protein and peptide letters · 2017Article
- Interorgan Communication Pathways in Physiology: Focus on Drosophila.Annual review of genetics · 2016Review
- Immuno-physiological adaptations confer wax moth Galleria mellonella resistance to Bacillus thuringiensis.Virulence · 2016Article
- The Female Post-Mating Response Requires Genes Expressed in the Secondary Cells of the Male Accessory Gland in Drosophila melanogaster.Genetics · 2016Article
- Growth-Blocking Peptides As Nutrition-Sensitive Signals for Insulin Secretion and Body Size Regulation.PLoS biology · 2016Article
- Bacteria Endosymbiont, Wolbachia, Promotes Parasitism of Parasitoid Wasp Asobara japonica.PloS one · 2015Article
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Antimicrobial peptides (AMPs), major innate immune effectors, are induced to protect hosts against invading microorganisms. AMPs are also induced under non-infectious stress; however, the signaling pathways of non-infectious stress-induced AMP expression are yet unclear. We demonstrated that growth-blocking peptide (GBP) is a potent cytokine that regulates stressor-induced AMP expression in insects.GBP overexpression in Drosophila elevated expression of AMPs.GBP-induced AMP expression did not require Toll and immune deficiency (Imd) pathway-related genes, but imd and basket were essential,indicating that GBP signaling in Drosophila did not use the orthodox Toll or Imd pathway but used the JNK pathway after association with the adaptor protein Imd. The enhancement of AMP expression by non-infectious physical or environmental stressors was apparent in controls but not in GBP-knockdown larvae. These results indicate that the Drosophila GBP signaling pathway mediates acute innate immune reactions under various stresses, regardless of whether they are infectious or non-infectious.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.