ArticleScientific reports2012
Zscan4 transiently reactivates early embryonic genes during the generation of induced pluripotent stem cells.
Article in Scientific reports, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
60 citing papers in PubMed, 86 citations in OpenAlex.
- Zscan4 as a Candidate Conveyor of Early Developmental Defects in O-GlcNAc Transferase Intellectual Disability.Molecular & cellular proteomics : MCP · 2025Article
- Genes as Genome Stabilizers in Pluripotent Stem Cells.Advances in experimental medicine and biology · 2025Review
- DiPRO1 distinctly reprograms muscle and mesenchymal cancer cells.EMBO molecular medicine · 2024Article
- Reprogramming Chromosome Ends by Functional Histone Acetylation.International journal of molecular sciences · 2024Article
- ZSCAN4-binding motif-TGCACAC is conserved and enriched in CA/TG microsatellites in both mouse and human genomes.DNA research : an international journal for rapid publication of reports on genes and genomes · 2024Article
- Article
- Zfp296 knockout enhances chromatin accessibility and induces a unique state of pluripotency in embryonic stem cells.Communications biology · 2023Article
- Genome architecture and totipotency: An intertwined relation during early embryonic development.BioEssays : news and reviews in molecular, cellular and developmental biology · 2022Article
- An ERK5-KLF2 signalling module regulates early embryonic gene expression and telomere rejuvenation in stem cells.The Biochemical journal · 2021Article
- Cleavage-embryo genes and transposable elements are regulated by histone variant H2A.X.The Journal of reproduction and development · 2021Article
- CTCF is a barrier for 2C-like reprogramming.Nature communications · 2021Article
- Transposable Element Dynamics and Regulation during Zygotic Genome Activation in Mammalian Embryos and Embryonic Stem Cell Model Systems.Stem cells international · 2021Review
- Article
- A distinct metabolic state arises during the emergence of 2-cell-like cells.EMBO reports · 2020Article
- The Role of Ubiquitination and SUMOylation in Telomere Biology.Current issues in molecular biology · 2020Review
- The role of telomere-binding modulators in pluripotent stem cells.Protein & cell · 2020Review
- Zscan4c activates endogenous retrovirus MERVL and cleavage embryo genes.Nucleic acids research · 2019Article
- The necessity of ZSCAN4 for preimplantation development and gene expression of bovine embryos.The Journal of reproduction and development · 2019Article
- GADD45 promotes locus-specific DNA demethylation and 2C cycling in embryonic stem cells.Genes & development · 2019Article
- Dppa2 and Dppa4 directly regulate the Dux-driven zygotic transcriptional program.Genes & development · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
The generation of induced pluripotent stem cells (iPSCs) by the forced expression of defined transcription factors in somatic cells holds great promise for the future of regenerative medicine. However, the initial reprogramming mechanism is still poorly understood. Here we show that Zscan4, expressed transiently in2-cell embryos and embryonic stem cells (ESCs), efficiently produces iPSCs from mouse embryo fibroblasts when coexpressed with Klf4, Oct4, and Sox2. Interestingly, the forced expression of Zscan4 is required onlyfor the first few days of iPSC formation. Microarray analysis revealed transient and early induction of preimplantation-specific genes in a Zscan4-dependent manner. Our work indicates that Zscan4 is a previously unidentified potent natural factor that facilitates the reprogramming process and reactivates early embryonic genes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.