ArticleScientific reports2011
Modeling dynamic interactions between pre-exposure prophylaxis interventions & treatment programs: predicting HIV transmission & resistance.
Article in Scientific reports, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 31 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Population-level mathematical modeling of antimicrobial resistance: a systematic review.BMC medicine · 2019Pooled it
- Dynamics of a two-group model for assessing the impacts of pre-exposure prophylaxis, testing and risk behaviour change on the spread and control of HIV/AIDS in an MSM population.Infectious Disease Modelling · 2024Article
- Are Unequal Policies in Pre-Exposure Prophylaxis Uptake Needed to Improve Equality? An Examination Among Men Who Have Sex with Men in Los Angeles County.AIDS patient care and STDs · 2022Article
- Potential Impact and Cost-Effectiveness of Condomless-Sex-Concentrated PrEP in KwaZulu-Natal Accounting for Drug Resistance.The Journal of infectious diseases · 2021Article
- Preference for and Efficacy of a PrEP Decision Aid for Women with Substance Use Disorders.Patient preference and adherence · 2021Article
- The impact, cost and cost-effectiveness of oral pre-exposure prophylaxis in sub-Saharan Africa: a scoping review of modelling contributions and way forward.Journal of the International AIDS Society · 2019Article
- Fuzzy-multidimensional deep learning for efficient prediction of patient response to antiretroviral therapy.Heliyon · 2019Article
- Review
- Mechanistic framework predicts drug-class specific utility of antiretrovirals for HIV prophylaxis.PLoS computational biology · 2019Article
- HIV drug resistance in sub-Saharan Africa: public health questions and the potential role of real-world data and mathematical modelling.Journal of virus eradication · 2018Article
- A modeling study of the Danish HIV epidemic in men who have sex with men: travel, pre-exposure prophylaxis and elimination.Scientific reports · 2018Article
- Article
- The Role of Phylogenetics as a Tool to Predict the Spread of Resistance.The Journal of infectious diseases · 2017Review
- Methodological concerns regarding a PrEP model.The Lancet. Infectious diseases · 2017Article
- Healthcare Access and PrEP Continuation in San Francisco and Miami After the US PrEP Demo Project.Journal of acquired immune deficiency syndromes (1999) · 2017Article
- Article
- Impact of Population Recruitment on the HIV Epidemics and the Effectiveness of HIV Prevention Interventions.Bulletin of mathematical biology · 2016Article
- Deciphering the Effects of Injectable Pre-exposure Prophylaxis for Combination Human Immunodeficiency Virus Prevention.Open forum infectious diseases · 2016Article
- Cost-effectiveness of Injectable Preexposure Prophylaxis for HIV Prevention in South Africa.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2016Article
- Cost-Effectiveness of HIV Preexposure Prophylaxis for People Who Inject Drugs in the United States.Annals of internal medicine · 2016Article
Corrections and comments
- Erratum issuedCorrigendum: Modeling dynamic interactions between pre-exposure prophylaxis interventions &treatment programs: predicting HIV transmission &resistance.2015 · Busang, Lesogo [corrected to Busang, Lesego]
Authors and funding
8 authors.
Funding
Abstract
Clinical trials have recently demonstrated the effectiveness of Pre-Exposure Prophylaxis (PrEP) in preventing HIV infection. Consequently, PrEP may soon be used for epidemic control. We model the dynamic interactions that will occur between treatment programs and potential PrEP interventions in resource-constrained countries. We determine the consequences for HIV transmission and drug resistance. We use response hypersurface modeling to predict the effect of PrEP on decreasing transmission as a function of effectiveness, adherence and coverage. We predict PrEP will increase need for second-line therapies (SLT) for treatment-naïve individuals, but could significantly decrease need for SLT for treatment-experienced individuals. If the rollout of PrEP is carefully planned it could increase the sustainability of treatment programs. If not, need for SLT could increase and the sustainability of treatment programs could be compromised. Our results show the optimal strategy for rolling out PrEP in resource-constrained countries is to begin around the "worst" treatment programs.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.