ArticleScientific reports2011
Dynein light chain 1 functions in somatic cyst cells regulate spermatogonial divisions in Drosophila.
Article in Scientific reports, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 31 citations in OpenAlex.
- Cyst stem cell lineage GAL4 transgenes are robustly expressed in hub cells of themicroPublication biology · 2026Article
- A polycistronic locus encodes both a tumor-suppressive microRNA and a long non-coding RNA regulating testis morphology in Drosophila.bioRxiv : the preprint server for biology · 2025Article
- Review
- Article
- Single-cell RNA-sequencing reveals pre-meiotic X-chromosome dosage compensation in Drosophila testis.PLoS genetics · 2021Article
- A Potential Role for the Gsdf-eEF1α Complex in Inhibiting Germ Cell Proliferation: A Protein-Interaction Analysis in Medaka (Oryzias latipes) From a Proteomics Perspective.Molecular & cellular proteomics : MCP · 2021Article
- Cyclin E and Cdk1 regulate the termination of germline transit-amplification process inCell cycle (Georgetown, Tex.) · 2020Article
- CG8005 Mediates Transit-Amplifying Spermatogonial Divisions via Oxidative Stress inOxidative medicine and cellular longevity · 2020Article
- Functional characterization of insect-specific RabX6 of Bombyx mori.Histochemistry and cell biology · 2019Article
- Somatic ERK activation during transit amplification is essential for maintaining the synchrony of germline divisions inOpen biology · 2018Article
- Contrasting patterns of evolutionary constraint and novelty revealed by comparative sperm proteomic analysis in Lepidoptera.BMC genomics · 2017Article
- Somatic PI3K activity regulates transition to the spermatocyte stages in Drosophila testis.Journal of biosciences · 2017Article
- Identification of Bovine Sperm Surface Proteins Involved in Carbohydrate-mediated Fertilization Interactions.Molecular & cellular proteomics : MCP · 2016Article
- Maintenance of Stem Cell Niche Integrity by a Novel Activator of Integrin Signaling.PLoS genetics · 2016Article
- Inverse regulation of two classic Hippo pathway target genes in Drosophila by the dimerization hub protein Ctp.Scientific reports · 2016Article
- Three RNA binding proteins form a complex to promote differentiation of germline stem cell lineage in Drosophila.PLoS genetics · 2014Article
- Investigating spermatogenesis in Drosophila melanogaster.Methods (San Diego, Calif.) · 2014Review
- The Drosophila cyst stem cell lineage: Partners behind the scenes?Spermatogenesis · 2012Article
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
Stem cell progeny often undergo transit amplifying divisions before differentiation. In Drosophila, a spermatogonial precursor divides four times within an enclosure formed by two somatic-origin cyst cells, before differentiating into spermatocytes. Although germline and cyst cell-intrinsic factors are known to regulate these divisions, the mechanistic details are unclear. Here, we show that loss of dynein-light-chain-1 (DDLC1/LC8) in the cyst cells eliminates bag-of-marbles (bam) expression in spermatogonia, causing gonial cell hyperplasia in Drosophila testis. The phenotype is dominantly enhanced by Dhc64C (cytoplasmic Dynein) and didum (Myosin V) loss-of-function alleles. Loss of DDLC1 or Myosin V in the cyst cells also affects their differentiation. Furthermore, cyst cell-specific loss of ddlc1 disrupts Armadillo, DE-cadherin and Integrin-βPS localizations in the cyst. Together, these results suggest that Dynein and Myosin V activities, and independent DDLC1 functions in the cyst cells organize the somatic microenvironment that regulates spermatogonial proliferation and differentiation.
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