ArticleScientific reports2011
Genetic variation and linkage disequilibrium in Bacillus anthracis.
Article in Scientific reports, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 11 citations in OpenAlex.
- Persistence in time: the hunt forApplied and environmental microbiology · 2025Article
- Linkage disequilibrium suggests genomic stability in Omicron clades of SARS-CoV-2 from the ASEAN countries.Journal of travel medicine · 2023Article
- Whole genome genetic variation and linkage disequilibrium in a diverse collection of Listeria monocytogenes isolates.PloS one · 2021Article
- Appendix Q: Recommendations for Developing Molecular Assays for Microbial Pathogen Detection Using Modern In Silico Approaches.Journal of AOAC International · 2020Article
- Phenotypic differentiation of Streptococcus pyogenes populations is induced by recombination-driven gene-specific sweeps.Scientific reports · 2016Article
- Characterizing the genetic basis of bacterial phenotypes using genome-wide association studies: a new direction for bacteriology.Genome medicine · 2014Article
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We performed whole-genome amplification followed by hybridization of custom-designed resequencing arrays to resequence 303 kb of genomic sequence from a worldwide panel of 39 Bacillus anthracis strains. We used an efficient algorithm contained within a custom software program, UniqueMER, to identify and mask repetitive sequences on the resequencing array to reduce false-positive identification of genetic variation, which can arise from cross-hybridization. We discovered a total of 240 single nucleotide variants (SNVs) and showed that B. anthracis strains have an average of 2.25 differences per 10,000 bases in the region we resequenced. Common SNVs in this region are found to be in complete linkage disequilibrium. These patterns of variation suggest there has been little if any historical recombination among B. anthracis strains since the origin of the pathogen. This pattern of common genetic variation suggests a framework for recognizing new or genetically engineered strains.
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