ArticleScientific reports2011
Inactivation of CBF/NF-Y in postnatal liver causes hepatocellular degeneration, lipid deposition, and endoplasmic reticulum stress.
Article in Scientific reports, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 25 citations in OpenAlex.
- Article
- The role(s) of NF-Y in development and differentiation.Cell death and differentiation · 2025Review
- Endoplasmic reticulum stress-mediated cell death in liver injury.Cell death & disease · 2022Review
- Article
- The transcription factor NF-Y participates to stem cell fate decision and regeneration in adult skeletal muscle.Nature communications · 2021Article
- Gene expression profiling in neuronal cells identifies a different type of transcriptome modulated by NF-Y.Scientific reports · 2020Article
- NF-Y Overexpression in Liver Hepatocellular Carcinoma (HCC).International journal of molecular sciences · 2020Article
- Regulation of hepatic gluconeogenesis by nuclear factor Y transcription factor in mice.The Journal of biological chemistry · 2018Article
- NF-Y (CBF) regulation in specific cell types and mouse models.Biochimica et biophysica acta. Gene regulatory mechanisms · 2017Review
- High fat diet-induced changes of mouse hepatic transcription and enhancer activity can be reversed by subsequent weight loss.Scientific reports · 2017Article
- Rice aleurone layer specific OsNF-YB1 regulates grain filling and endosperm development by interacting with an ERF transcription factor.Journal of experimental botany · 2016Article
- Differential roles of NF-Y transcription factor in ER chaperone expression and neuronal maintenance in the CNS.Scientific reports · 2016Article
- A high definition look at the NF-Y regulome reveals genome-wide associations with selected transcription factors.Nucleic acids research · 2016Article
- Context-specific role of SOX9 in NF-Y mediated gene regulation in colorectal cancer cells.Nucleic acids research · 2015Article
- Histone-fold domain protein NF-Y promotes chromatin accessibility for cell type-specific master transcription factors.Molecular cell · 2014Article
- Nuclear factor-erythroid 2-related factor 1 regulates expression of proteasome genes in hepatocytes and protects against endoplasmic reticulum stress and steatosis in mice.The FEBS journal · 2013Article
- Diverse Hap43-independent functions of the Candida albicans CCAAT-binding complex.Eukaryotic cell · 2013Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
We previously demonstrated that CBF activity is needed for cell proliferation and early embryonic development. To examine the in vivo function of CBF in differentiated hepatocytes, we conditionally deleted CBF-B in hepatocytes after birth. Deletion of CBF-B resulted in progressive liver injury and severe hepatocellular degeneration 4 weeks after birth. Electron microscopic examination demonstrated pleiotropic changes of hepatocytes including enlarged cell and nuclear size, intracellular lipid deposition, disorganized endoplasmic reticulum, and mitochondrial abnormalities. Gene expression analyses showed that deletion of CBF-B activated expression of specific endoplasmic reticulum (ER) stress-regulated genes. Inactivation of CBF-B also inhibited expression of C/EBP alpha, an important transcription factor controlling various metabolic processes in adult hepatocytes. Altogether, our study reveals for the first time that CBF is a key transcription factor controlling ER function and metabolic processes in mature hepatocytes.
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Registered trials
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