ArticleScientific reports2011
Location, location, location: Beneficial effects of autologous fat transplantation.
Article in Scientific reports, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 26 citations in OpenAlex.
- EBF2 variant identified in a patient with atypical partial lipodystrophy causes adipose fibrosis and dysfunction.The Journal of clinical investigation · 2026Article
- Metabolic effects of lipectomy and of adipose tissue transplantation.Obesity (Silver Spring, Md.) · 2023Review
- Using adipose-derived mesenchymal stem cells to fight the metabolic complications of obesity: Where do we stand?Obesity reviews : an official journal of the International Association for the Study of Obesity · 2022Review
- Epigenetic and Transcriptome Profiling Identifies a Population of Visceral Adipose-Derived Progenitor Cells with the Potential to Differentiate into an Endocrine Pancreatic Lineage.Cell transplantation · 2019Article
- Fibroblast growth factor 21 increases insulin sensitivity through specific expansion of subcutaneous fat.Nature communications · 2018Article
- Muscle-specific downregulation of GR levels inhibits adipogenesis in porcine intramuscular adipocyte tissue.Scientific reports · 2017Article
- Autologous subcutaneous adipose tissue transplants improve adipose tissue metabolism and reduce insulin resistance and fatty liver in diet-induced obesity rats.Physiological reports · 2016Article
- Diet-induced variability of the resistin gene (Retn) transcript level and methylation profile in rats.BMC genetics · 2015Article
- Molecular heterogeneities of adipose depots - potential effects on adipose-muscle cross-talk in humans, mice and farm animals.Journal of genomics · 2014Review
- The developmental origins of adipose tissue.Development (Cambridge, England) · 2013Review
- Gene expression profiling reveals distinct features of various porcine adipose tissues.Lipids in health and disease · 2013Article
- Effects of endogenous androgens and abdominal fat distribution on the interrelationship between insulin and non-insulin-mediated glucose uptake in females.The Journal of clinical endocrinology and metabolism · 2013Article
- Therapeutic value of brown adipose tissue: Correcting metabolic disease through generating healthy fat.Adipocyte · 2012Article
- An atlas of DNA methylomes in porcine adipose and muscle tissues.Nature communications · 2012Article
- Genome-wide DNA methylation changes between the superficial and deep backfat tissues of the pig.International journal of molecular sciences · 2012Article
- Co-methylated genes in different adipose depots of pig are associated with metabolic, inflammatory and immune processes.International journal of biological sciences · 2012Article
Corrections and comments
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Authors and funding
12 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Visceral adiposity is a risk factor for cardiovascular disorders, type 2 diabetes mellitus (T2D) and associated metabolic diseases. Sub-cutaneous fat is believed to be intrinsically different from visceral fat. To understand molecular mechanisms involved in metabolic advantages of fat transplantation, we studied a rat model of diet-induced adiposity. Adipokine genes (Adiponectin, Leptin, Resistin and Visfatin) were expressed at 10,000 to a million-fold lower in visceral fat depot as compared to peripheral (thigh/chest) fat depots. Interestingly, autologous transplantation of visceral fat to subcutaneous sites resulted in increased gene transcript abundance in the grafts by 3 weeks post-transplantation, indicating the impact of local (residence) factors influencing epigenetic memory. We show here that active transcriptional state of adipokine genes is linked with glucose mediated recruitment of enzymes that regulate histone methylation. Adipose depots have "residence memory" and autologous transplantation of visceral fat to sub-cutaneous sites offers metabolic advantage.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.