ArticleScientific reports2011
β-catenin is a molecular switch that regulates transition of cell-cell adhesion to fusion.
Article in Scientific reports, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 32 citations in OpenAlex.
- Small-molecule LF3 alleviates angiotensin II-induced cardiac dysfunction via attenuating cardiac fibrosis.Naunyn-Schmiedeberg's archives of pharmacology · 2026Article
- Implications of Heterotypic Cell Fusion in Cancer.Advances in experimental medicine and biology · 2026Review
- Mechanisms of Cell Fusion in Cancer.Results and problems in cell differentiation · 2024Review
- Transient suppression of Wnt signaling in poor-quality buffalo oocytes improves their developmental competence.Frontiers in veterinary science · 2023Article
- Extracellular Events Involved in Cancer Cell-Cell Fusion.International journal of molecular sciences · 2022Review
- Testis-Specific Isoform of NaInternational journal of molecular sciences · 2022Review
- Signaling Proteins Recruited to the Sperm Binding Site: Role of β-Catenin and Rho A.Frontiers in cell and developmental biology · 2022Article
- Article
- Epidermal growth factor receptor signaling uncouples germ cells from the somatic follicular compartment at ovulation.Nature communications · 2021Article
- MicroRNA-451 is downregulated in the follicular fluid of women with endometriosis and influences mouse and human embryonic potential.Reproductive biology and endocrinology : RB&E · 2019Article
- Testis-Specific Isoform of Na/K-ATPase (ATP1A4) Interactome in Raft and Non-Raft Membrane Fractions from Capacitated Bovine Sperm.International journal of molecular sciences · 2019Article
- Sperm-oocyte contact induces outside-in signaling via PYK2 activation.Developmental biology · 2017Article
- MiRNA-320 in the human follicular fluid is associated with embryo quality in vivo and affects mouse embryonic development in vitro.Scientific reports · 2015Article
- Requirement of the transcription factor USF1 in bovine oocyte and early embryonic development.Reproduction (Cambridge, England) · 2015Article
- Critical role of exosomes in sperm-egg fusion and virus-induced cell-cell fusion.Reproductive medicine and biology · 2013Review
- β-catenin functions pleiotropically in differentiation and tumorigenesis in mouse embryo-derived stem cells.PloS one · 2013Article
- CD81 and CD9 work independently as extracellular components upon fusion of sperm and oocyte.Biology open · 2012Article
- Na/K-ATPase and Regulation of Sperm Function.Animal reproductionArticle
Corrections and comments
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Authors and funding
16 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
When a sperm and an oocyte unite upon fertilization, their cell membranes adhere and fuse, but little is known about the factors regulating sperm-oocyte adhesion. Here we explored the role of β-catenin in sperm-oocyte adhesion. Biochemical analysis revealed that E-cadherin and β-catenin formed a complex in oocytes and also in sperm. Sperm-oocyte adhesion was impaired when β-catenin-deficient oocytes were inseminated with sperm. Furthermore, expression of β-catenin decreased from the sperm head and the site of an oocyte to which a sperm adheres after completion of sperm-oocyte adhesion. UBE1-41, an inhibitor of ubiquitin-activating enzyme 1, inhibited the degradation of β-catenin, and reduced the fusing ability of wild-type (but not β-catenin-deficient) oocytes. These results indicate that β-catenin is not only involved in membrane adhesion, but also in the transition to membrane fusion upon fertilization.
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Registered trials
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