ArticleScientific reports2011
A non-coding RNA of insect HzNV-1 virus establishes latent viral infection through microRNA.
Article in Scientific reports, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 48 citations in OpenAlex.
- Viral Prevalence and Genomic Xenology in the Coevolution of HzNV-2 (Nudiviridae) with HostInsects · 2023Article
- Transcription Profile and Genomic Variations of Oryctes Rhinoceros Nudivirus in Coconut Rhinoceros Beetles.Journal of virology · 2020Article
- ICTV Virus Taxonomy Profile:The Journal of general virology · 2020Article
- MicroRNAs derived from the insect virus HzNV-1 promote lytic infection by suppressing histone methylation.Scientific reports · 2018Article
- Adventitious viruses in insect cell lines used for recombinant protein expression.Protein expression and purification · 2018Review
- Expression Profile ofFrontiers in microbiology · 2018Article
- Viral lncRNA: A regulatory molecule for controlling virus life cycle.Non-coding RNA research · 2017Review
- Viral Delivery of dsRNA for Control of Insect Agricultural Pests and Vectors of Human Disease: Prospects and Challenges.Frontiers in physiology · 2017Review
- Covert Infection of Insects by Baculoviruses.Frontiers in microbiology · 2017Review
- The Discovery, Distribution, and Evolution of Viruses Associated with Drosophila melanogaster.PLoS biology · 2015Article
- Polydnaviruses: From discovery to current insights.Virology · 2015Review
- Role of microRNAs in arbovirus/vector interactions.Viruses · 2014Review
- Peste des petits ruminants virus infection of small ruminants: a comprehensive review.Viruses · 2014Review
- Human RNAi pathway: crosstalk with organelles and cells.Functional & integrative genomics · 2014Review
- MicroRNA-like viral small RNA from Dengue virus 2 autoregulates its replication in mosquito cells.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Review
- Virus-encoded microRNAs: an overview and a look to the future.PLoS pathogens · 2012Review
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Heliothis zea nudivirus-1 (HzNV-1) is an insect virus previously known as Hz-1 baculovirus. One of its major early genes, hhi1, is responsible for the establishment of productive viral infection; another gene, pag1, which expresses a non-coding RNA, is the only viral transcript detectable during viral latency. Here we showed that this non-coding RNA was further processed into at least two distinct miRNAs, which targeted and degraded hhi1 transcript. This is a result strikingly similar to a recent report that herpes simplex virus produces tightly-regulated latent specific miRNAs to silence its own key early transcripts. Nevertheless, proof for the establishment of viral latency by miRNA is still lacking. We further showed that HzNV-1 latency could be directly induced by pag1-derived miRNAs in cells infected with a pag1-deleted, latency-deficient virus. This result suggests the existence of a novel mechanism, where miRNAs can be functional for the establishment of viral latency.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.