ArticleScientific reports2011
Population diversity and function of hyperpolarization-activated current in olfactory bulb mitral cells.
Article in Scientific reports, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers.
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Who cites it
54 citing papers in PubMed, 71 citations in OpenAlex.
- Target-dependent routing of sensory information in the olfactory system.Communications biology · 2026Article
- The HCN4 channel modulates external tufted cell burst firing.Journal of neurophysiology · 2026Article
- Adult-neurogenesis allows for representational stability and flexibility in early olfactory system.eLife · 2026Article
- Neuroinflammation causes mitral cell dysfunction and olfactory impairment in a multiple sclerosis model.Journal of neuroinflammation · 2025Article
- Ex Vivo Functional Characterization of Mouse Olfactory Bulb Projection Neurons Reveals a Heterogeneous Continuum.eNeuro · 2025Article
- Quantitative analyses of how optimally heterogeneous neural codes maximize neural information in jittery transmission environments.Scientific reports · 2024Article
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- Electrophysiological and morphological characterization of single neurons in intact human brain organoids.Journal of neuroscience methods · 2023Article
- A biophysical and statistical modeling paradigm for connecting neural physiology and function.Journal of computational neuroscience · 2023Article
- Advances in the Electrophysiological Recordings of Long-Term Potentiation.International journal of molecular sciences · 2023Review
- Excitable Axonal Domains Adapt to Sensory Deprivation in the Olfactory System.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Function and Plasticity of Electrical Synapses in the Mammalian Brain: Role of Non-Junctional Mechanisms.Biology · 2022Review
- IProgress in biophysics and molecular biology · 2021Review
- Changes in pairwise correlations during running reshape global network state in the main olfactory bulb.Journal of neurophysiology · 2021Article
- Stimulus Driven Functional Transformations in the Early Olfactory System.Frontiers in cellular neuroscience · 2021Article
- Article
- Subpopulations of Projection Neurons in the Olfactory Bulb.Frontiers in neural circuits · 2020Review
- Regional differences in mitral cell development in mouse olfactory bulb.The Journal of comparative neurology · 2019Article
- Enhanced Activation of HCN Channels Reduces Excitability and Spike-Timing Regularity in Maturing Vestibular Afferent Neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Respiratory motoneuron properties during the transition from gill to lung breathing in the American bullfrog.American journal of physiology. Regulatory, integrative and comparative physiology · 2019Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Although neurons are known to exhibit a broad array of intrinsic properties that impact critically on the computations they perform, very few studies have quantified such biophysical diversity and its functional consequences. Using in vivo and in vitro whole-cell recordings here we show that mitral cells are extremely heterogeneous in their expression of a rebound depolarization (sag) at hyperpolarized potentials that is mediated by a ZD7288-sensitive current with properties typical of hyperpolarization-activated cyclic nucleotide gated (HCN) channels. The variability in sag expression reflects a functionally diverse population of mitral cells. For example, those cells with large amplitude sag exhibit more membrane noise, a lower rheobase and fire action potentials more regularly than cells where sag is absent. Thus, cell-to-cell variability in sag potential amplitude reflects diversity in the integrative properties of mitral cells that ensures a broad dynamic range for odor representation across these principal neurons.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.