ArticleScientific reports2011
Disruption of plasmepsin-4 and merozoites surface protein-7 genes in Plasmodium berghei induces combined virulence-attenuated phenotype.
Article in Scientific reports, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 25 citations in OpenAlex.
- Plasmepsins as Antimalarial Drug Targets-Then, Now, and the Future.Medicinal research reviews · 2026Review
- Article
- T. brucei infections abrogate diverse plasma cell-mediated effector B cell responses, independently of their specificity, affinity and host genetic background.PLoS neglected tropical diseases · 2020Article
- Essential role of GEXP15, a specific Protein Phosphatase type 1 partner, in Plasmodium berghei in asexual erythrocytic proliferation and transmission.PLoS pathogens · 2019Article
- Clinical expression and antigenic profiles of a Plasmodium vivax vaccine candidate: merozoite surface protein 7 (PvMSP-7).Malaria journal · 2019Article
- Transcriptomic profiling of microglia reveals signatures of cell activation and immune response, during experimental cerebral malaria.Scientific reports · 2016Article
- Aspartyl Proteinases of Eukaryotic Microbial Pathogens: From Eating to Heating.PLoS pathogens · 2016Review
- Protection against malaria in mice is induced by blood stage-arresting histamine-releasing factor (HRF)-deficient parasites.The Journal of experimental medicine · 2016Article
- Review
- Disruption of Parasite hmgb2 Gene Attenuates Plasmodium berghei ANKA Pathogenicity.Infection and immunity · 2015Article
- P-selectin is a host receptor for Plasmodium MSP7 ligands.Malaria journal · 2015Article
- Enzymatic Characterization of Recombinant Food Vacuole Plasmepsin 4 from the Rodent Malaria Parasite Plasmodium berghei.PloS one · 2015Article
- Antibodies to PfSEA-1 block parasite egress from RBCs and protect against malaria infection.Science (New York, N.Y.) · 2014Article
- Plasmodium attenuation: connecting the dots between early immune responses and malaria disease severity.Frontiers in microbiology · 2014Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Blood stage malaria parasites causing a mild and self limited infection in mice have been obtained with either radiation or chemical mutagenesis showing the possibility of developing an attenuated malaria vaccine. Targeted disruption of plasmepsin-4 (pm4) or the merozoite surface protein-7 (msp7) genes also induces a virulence-attenuated phenotype in terms of absence of experimental cerebral malaria (ECM), delayed increase of parasitemia and reduced mortality rate. The decrease in virulence in parasites lacking either pm4 or msp7 is however incomplete and dependent on the parasite and mouse strain combination. The sequential disruption of both genes induced remarkable virulence-attenuated blood-stage parasites characterized by a self-resolving infection with low levels of parasitemia and no ECM. Furthermore, convalescent mice were protected against the challenge with P. berghei or P. yoelii parasites for several months. These observations provide a proof-of-concept step for the development of human malaria vaccines based on genetically attenuated blood-stage parasites.
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